Table 3.
Top 5 upstream regulators predicted to mimic TREM2 KO (group 1 genes)
| Name | Synonyms | Function | Activation Z-score | p value of overlap | Number of group 1 genes regulated |
|---|---|---|---|---|---|
| Interleukin-10 | IL10(A), CSIF, GVHDS, TGIF | Cytokine | + 2.13 | 8 × 10− 22 | 60 |
| Interleukin-27 | IL27(A), IL30, P38 | Cytokine | + 2.57 | 2 × 10− 21 | 36 |
| Fas receptor | FAS, FasR, FASTM, ALPS1A, APO-1, APT1, CD95, TNFRSF6 | Receptor for Fas ligand, initiates apoptosis | + 2.44 | 3 × 10− 21 | 56 |
| Interferon-α2 | IFNA2(A/B/C) | Cytokine, type I interferon | + 3.46 | 2 × 10−19 | 43 |
| Signal transducer and activator of transcription 1 | STAT1, ISGF-3, CANDF7, IMD31(A/B/C), STAT91 | Transcription factor downstream of interferon receptors | + 2.48 | 2 × 10−15 | 47 |
Upstream regulators predicted by IPA to be activatory, ordered by lowest p value