Table 2.
Associations between pCR and clinical/pathologic parameters from logistic regression analysis
Variables | N | pCR | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|---|---|
P | OR | 95% CI | P | OR | 95% CI | ||||
Age, years | < 50 | 66 (60.6) | 5 (7.6) | 0.817 | 1 | 0.656 | 1 | ||
≥50 | 43 (39.4) | 3 (7.0) | 0.915 | 0.207–4.043 | 1.231 | 0.266–8.164 | |||
Menopausal status | Pre | 75 (68.8) | 5 (6.7) | 1 | |||||
Post | 34 (31.2) | 3 (8.8) | 0.690 | 1.355 | 0.305–6.027 | ||||
Clinical stage | 2A | 10 (9.2) | 0 | 0.997 | – | – | 0.890 | – | – |
2B | 36 (33.0) | 3 (37.5) | |||||||
3A | 48 (44.0) | 4 (50.0) | |||||||
3B,C | 15 (13.8) | 1 (12.5) | |||||||
Tumor size | 1 | 8 (7.3) | 0 | 0.996 | 1 | ||||
2 | 77 (70.6) | 6 (7.8) | – | – | |||||
3–4 | 24 (22) | 2 (8.3) | – | – | |||||
LN involvement | 0 | 8 (7.3) | 0 | 0.979 | 1 | ||||
1 | 46 (42.2) | 4 (8.7) | – | – | |||||
2 | 45 (41.3) | 3 (6.7) | – | – | |||||
3 | 10 (9.2) | 1 (10.0) | – | – | |||||
ER, Allred score | 0–4 | 18 (16.5) | 3 (16.7) | 0.114 | 1 | ||||
5–8 | 91 (83.5) | 5 (5.5) | 0.291 | 0.63–1.346 | |||||
PR, Allred score | 0–4 | 27 (24.8) | 2 (25) | 0.988 | 1 | ||||
5–8 | 82 (75.2) | 6 (75) | 0.987 | 0.187–5.205 | |||||
Ki67 index, % | < 14 | 54 (49.5) | 2 (3.7) | 0.168 | 1 | ||||
≥14 | 55 (50.5) | 6 (10.9) | 3.184 | 0.613–16.531 | |||||
Molecular subtype | Luminal A-like | 75 (68.8) | 5 (4.2) | 0.274 | 1 | 0.294 | 1 | ||
Luminal B-like | 34 (31.2) | 3 (9.8) | 2.509 | 0.483–13.032 | 2.570 | 0.441–14.973 | |||
Regimen | AC4 or TC | 4 (3.7) | 1 (25.0) | 0.206 | 1 | ||||
AC4T4 | 105 (96.3) | 7 (6.7) | 0.214 | 0.020–2.338 | |||||
pSUVmax | < 9.55 | 70 (64.2) | 1 (1.4) | 0.013 | 1 | 0.013 | 1 | ||
≥ 9.55 | 39 (35.8) | 7 (17.9) | 15.094 | 1.782–127.880 | 17.452 | 1.847–164.892 |
Numbers in parentheses are percentages. Abbreviations: ER Estrogen receptor; PR Progesterone receptor; pSUVmax SUVmax of primary breast tumor, CR Complete response, AC Anthracycline + cyclophosphamide, T Taxane, TC Docetaxel + cyclophosphamide, BCS Breast conserving surgery, OR Odds ratio, CI Confidence interval