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. 2020 Nov 16;20:1106. doi: 10.1186/s12885-020-07505-w

Table 2.

Associations between pCR and clinical/pathologic parameters from logistic regression analysis

Variables N pCR Univariate analysis Multivariate analysis
P OR 95% CI P OR 95% CI
Age, years < 50 66 (60.6) 5 (7.6) 0.817 1 0.656 1
≥50 43 (39.4) 3 (7.0) 0.915 0.207–4.043 1.231 0.266–8.164
Menopausal status Pre 75 (68.8) 5 (6.7) 1
Post 34 (31.2) 3 (8.8) 0.690 1.355 0.305–6.027
Clinical stage 2A 10 (9.2) 0 0.997 0.890
2B 36 (33.0) 3 (37.5)
3A 48 (44.0) 4 (50.0)
3B,C 15 (13.8) 1 (12.5)
Tumor size 1 8 (7.3) 0 0.996 1
2 77 (70.6) 6 (7.8)
3–4 24 (22) 2 (8.3)
LN involvement 0 8 (7.3) 0 0.979 1
1 46 (42.2) 4 (8.7)
2 45 (41.3) 3 (6.7)
3 10 (9.2) 1 (10.0)
ER, Allred score 0–4 18 (16.5) 3 (16.7) 0.114 1
5–8 91 (83.5) 5 (5.5) 0.291 0.63–1.346
PR, Allred score 0–4 27 (24.8) 2 (25) 0.988 1
5–8 82 (75.2) 6 (75) 0.987 0.187–5.205
Ki67 index, % < 14 54 (49.5) 2 (3.7) 0.168 1
≥14 55 (50.5) 6 (10.9) 3.184 0.613–16.531
Molecular subtype Luminal A-like 75 (68.8) 5 (4.2) 0.274 1 0.294 1
Luminal B-like 34 (31.2) 3 (9.8) 2.509 0.483–13.032 2.570 0.441–14.973
Regimen AC4 or TC 4 (3.7) 1 (25.0) 0.206 1
AC4T4 105 (96.3) 7 (6.7) 0.214 0.020–2.338
pSUVmax <  9.55 70 (64.2) 1 (1.4) 0.013 1 0.013 1
≥ 9.55 39 (35.8) 7 (17.9) 15.094 1.782–127.880 17.452 1.847–164.892

Numbers in parentheses are percentages. Abbreviations: ER Estrogen receptor; PR Progesterone receptor; pSUVmax SUVmax of primary breast tumor, CR Complete response, AC Anthracycline + cyclophosphamide, T Taxane, TC Docetaxel + cyclophosphamide, BCS Breast conserving surgery, OR Odds ratio, CI Confidence interval