Table 2.
Overall survival according to ICC-positive cell type status in bone marrow
| ICC-type | Level | N | Incidentcases | Person months | HR(95%CI) | p-value | Mean OS(95%CI) |
|---|---|---|---|---|---|---|---|
| Overall survival, resected cancers | |||||||
| TC | Positive | 6 | 5 | 217.5 | 1.1 (0.4–2.3) | 0.865 | 36.2 (11.3–61.2) |
| Negative | 162 | 133 | 5293.6 | 37.1 (31.6–42.6) | |||
| UIC | Positive | 10 | 7 | 488.1 | 0.6 (0.3–1.3) | 0.197 | 52.5 (27.2–77.7) |
| Negative | 164 | 136 | 5144.0 | 35. 6 (30.2–40.9) | |||
| HC | Positive | 16 | 14 | 431.6 | 1.3 (0.7–2.2) | 0.386 | 29.6 (14.3–44.8) |
| Negative | 153 | 125 | 5006.5 | 37.3 (31.6–43.1) | |||
| QHC | Positive | 12 | 10 | 419.0 | 0.9 (.5–1.8) | 0.795 | 37.1 (18.1–56.0) |
| Negative | 123 | 102 | 3817.1 | 35.5 (29.2–41.8) | |||
| Overall survival, advanced cancers | |||||||
| TC | Positive | 2 | 2 | 7.9 | 3.4 (0.7–15.4) | 0.114 | 3.9 (0.8–7.1)s |
| Negative | 29 | 29 | 298.8 | 10.3 (7.4–13.2) | |||
| UIC | Positive | 0 | 0 | – | – | ||
| Negative | 31 | 31 | 306.6 | 9.9 (7.1–12.7) | |||
| HC | Positive | 2 | 2 | 14.3 | 1.6 (0.4–7.2) | 0.522 | 7.2 (4.0–10.3) |
| Negative | 28 | 28 | 266.6 | 9.5 (6.5–12.5) | |||
| QHC | Positive | 3 | 3 | 16.6 | 2.1 (0.6–7.2) | 0.262 | 5.5 (1.9–9.2) |
| Negative | 25 | 25 | 248.5 | 9.9 (6.5–13.4) | |||
| Overall survival, benign disease | |||||||
| TC | Positive | 4 | 2 | 256.1 | 4.0 (0.7–22.6) | 0.114 | 65.3 (53.0–77.6) |
| Negative | 25 | 7 | 1929.4 | 92.2 (82.7–101.7) | |||
| UIC | Positive | 2 | 2 | 143.0 | 5.7 (1.1–25.5) | 0.039 | 71.5 (52.9–90.1) |
| Negative | 28 | 7 | 1796.9 | 92.6 (83.2–101.9) | |||
| HC | Positive | 3 | 2 | 202.3 | 4.7 (0.9–25.7) | 0.075 | 69.4 (43.1–95.7) |
| Negative | 26 | 6 | 1867.3 | 93.7 (84.3–103.2) | |||
| QHC | Positive | 3 | 2 | 202.3 | 3.9 (0.7–21.6) | 0.114 | 5.5 (1.9–9.2) |
| Negative | 22 | 5 | 1639.1 | 9.9 (6.5–13.4) | |||
| Disease free survival, resected cancers | |||||||
| TC | Positive | 6 | 6 | 112.4 | 1.3 (0.6–3.0) | 0.525 | 18.7 (4.5–33.0) |
| Negative | 162 | 126 | 4022.2 | 32.2 (25.9–38.5) | |||
| UIC | Positive | 10 | 5 | 441.8 | 0.4 (0.2–1.0) | 0.040 | 62.1 (37.1–87.1) |
| Negative | 164 | 132 | 3785.8 | 29.4 (23.5–35.4) | |||
| HC | Positive | 16 | 16 | 299.4 | 1.4 (0.8–2.5) | 0.277 | 22.6 (5.7–39.5) |
| Negative | 153 | 120 | 3774.0 | 31.9 (25.5–38.3) | |||
| QHC | Positive | 12 | 10 | 340.7 | 1.0 (0.5–1.9) | 0.973 | 30.1 (10. 1–50.8) |
| Negative | 123 | 96 | 2825.6 | 30.8 (23.7–37.8) | |||
Detailed survival analysis for patients with (pos.) or without (neg.) ICC-positive cells in the bone marrow in the indicated morphological cell categories. HR and p-values were computed by Cox-regression analysis. The number of patients analysed may differ from group size for cases with inconclusive ICC-results