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. 2020 Nov 16;11:485. doi: 10.1186/s13287-020-02000-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — MCP-induced deacetylations via SIRT1 promote nuclear accumulation of β-catenin in C17.2-NSCs. a Western immunoblots of Ac-β-catenin after glutamic acid stimulation reperfusion of indicated time point. b Quantitative analysis of the expression of Ac-β-catenin compared with that of β-actin from indicated group. c Fractionated extracts analysis. Western immunoblots of β-catenin in nuclear and cytoplasmic from indicated group. d, e Statistical analysis for β-catenin nuclear accumulation. β-actin or LaminB1 was used for signal normalization. f, h Western immunoblots of the nuclear accumulation of β-catenin and Ac-β-catenin (IP, acety Lys; IB, β-catenin) from indicated group in glutamate-treated C17.2-NSCs. g Quantitative analysis of the nuclear accumulation of β-catenin and Ac-β-catenin treatment with RSV or NA (f). i Quantitative analysis of the nuclear accumulation of β-catenin and Ac-β-catenin treatment with MCPs or SIRT1-siRNA (h). Data were given as mean ± SD according to ANOVA with n = 3 independent experiments in triplicate per group. ^aP < 0.05 vs. Con, ^bP < 0.05 vs. RSV25μM or MCP group