Table 3.
Univariate and multivariate Cox regression analyses for patients in the training cohort
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | |
| Age, years | 0.986 (0.971–1.000) | 0.052 | ||
| Sex, male vs. female | 1.675 (0.964–2.911) | 0.067 | ||
| BMI, Kg/m2 | ||||
| <18.5vs.18.5–25 | 0.944 (0.455–1.957) | 0.876 | ||
| 25vs.18.5–25 | 1.171 (0.539–2.541) | 0.691 | ||
| HBsAg, Positive vs. Negative | 1.950 (1.079–3.523) | 0.027 | ||
| HBV-DNA, copies/ml, <103 vs. ≥ 103 | 1.740 (1.223–2.476) | 0.002 | ||
| Liver cirrhosis, Present vs. Absent | 0.826 (0.583–1.171) | 0.283 | ||
| Child-Pugh classification, B vs. A | 1.684 (0.825–3.438) | 0.152 | ||
| Previous abdominal surgery, Present vs. Absent | 0.893 (0.562–1.420) | 0.632 | ||
| Comorbidities, Present vs. Absent | 1.016 (0.668–1.546) | 0.941 | ||
| AFP, ng/mL, ≥ 400vs.<400 | 1.931 (1.388–2.688) | < 0.001 | 1.566 (1.101–2.226) | 0.013 |
| CEA, ng/mL, Normal vs. Abnormal | 0.656 (0.419–1.027) | 0.065 | ||
| CA19–9, U/ml, Normal vs. Abnormal | 1.131 (0.807–1.585) | 0.474 | ||
| TBIL, umol/L | 1.000 (0.988–1.013) | 0.940 | ||
| DBIL, umol/L | 0.999 (0.982–1.016) | 0.901 | ||
| ALT, IU/L | 1.000 (0.999–1.002) | 0.823 | ||
| AST, IU/L | 1.000 (0.999–1.002) | 0.423 | ||
| Albumin, g/L, <35vs. ≥ 35 | 1.322 (0.732–2.390) | 0.355 | ||
| NLR | 1.085 (1.030–1.143) | 0.002 | ||
| PLR | 1.006 (1.004–1.009) | < 0.001 | 1.004 (1.001–1.007) | 0.010 |
| ASA grade, III vs. II | 1.362 (0.910–2.039) | 0.133 | ||
| Largest tumor size, cm | 1.193 (1.145–1.244) | < 0.001 | 1.084 (1.027–1.145) | 0.003 |
| Tumor number, Solitary vs. Multiple | 1.314 (0.710–2.432) | 0.384 | ||
| Hepatectomy, Anatomical vs. Nonanatomical | 0.755 (0.538–1.060) | 0.105 | ||
| Hemorrhage, ml, ≥ 200vs.<200 | 1.927 (1.310–2.836) | 0.001 | ||
| Intraoperative transfusion, Yes vs. No | 1.860 (1.104–3.132) | 0.020 | ||
| Differentiation, poor vs. Well-moderate | 1.598 (1.148–2.225) | 0.006 | ||
| MVI, Present vs. Absent | 3.524 (2.524–4.921) | <0.001 | 2.509 (1.751–3.594) | <0.001 |
| Capsule, Incomplete vs. Complete | 1.891 (1.324–2.702) | < 0.001 | ||
| Rad-score | 1.493 (1.324–1.684) | < 0.001 | 1.398 (1.188–1.646) | <0.001 |
ASA American Society of Anesthesiologists, BMI Body mass index, AFP α-fetoprotein, ALT Alanine transaminase, AST Aspartate aminotransferase, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet lymphocyte ratio, MVI Microvascular invasion, Rad-score Radiomics score