Table 4.
Relationship between the incidence of the key secondary endpoint and the AIP expressed as a categorical variable
| Variables | Univariate analysis HR (95% CI) |
P-value | Multivariate analysis HR (95% CI) |
P-value |
|---|---|---|---|---|
| AIP quartiles | ||||
| Q1 | Reference | Reference | ||
| Q2 | 1.380 (0.555–3.432) | 0.488 | 0.985 (0.362–2.679) | 0.976 |
| Q3 | 2.020 (0.865–4.720) | 0.104 | 1.822 (0.734–4.524) | 0.196 |
| Q4 | 2.‘477 (1.085–5.659) | 0.031 | 2.571 (1.027–6.440) | 0.044 |
| Age | 1.042 (1.013–1.072) | 0.004 | 1.016 (0.984–1.048) | 0.331 |
| BMI | 0.915 (0.834–1.004) | 0.062 | 0.861 (0.775–0.956) | 0.005 |
| Hypertension | 1.333 (0.725–2.450) | 0.354 | 1.303 (0.664–2.558) | 0.442 |
| Past PCI | 1.904 (1.096–3.309) | 0.022 | 2.124 (1.119–4.030) | 0.021 |
| PAD | 5.804 (3.402–9.902) | < 0.001 | 3.068 (1.677–5.613) | < 0.001 |
| Cardiac failure | 6.939 (3.993–12.061) | < 0.001 | 1.870 (0.774–4.517) | 0.164 |
| LVEF | 0.924 (0.902–0.946) | < 0.001 | 0.947 (0.912–0.983) | 0.004 |
| SCr | 1.025 (1.014–1.036) | < 0.001 | 1.010 (0.997–1.022) | 0.123 |
| LDL-C | 1.064 (0.774–1.463) | 0.702 | 1.102 (0.731–1.661) | 0.644 |
| Glycated haemoglobin | 1.090 (0.882–1.347) | 0.425 | 1.243 (0.974–1.587) | 0.081 |
| Clinical presentation | ||||
| UAP | Reference | Reference | ||
| NSTEMI | 1.333 (0.622–2.857) | 0.460 | 0.462 (0.187–1.143) | 0.095 |
| STEMI | 1.920 (0.896–4.115) | 0.094 | 0.880 (0.375–2.061) | 0.768 |
| CAD severity | ||||
| One-vessel disease | Reference | Reference | ||
| Two-vessel disease | 0.201 (0.037–1.096) | 0.064 | 0.060 (0.009–0.399) | 0.004 |
| LM/three-vessel disease | 1.910 (0.689–5.296) | 0.214 | 0.476 (0.142–1.593) | 0.228 |
| Lesions > 20 mm long | 2.681 (1.411–5.029) | 0.003 | 1.776 (0.866–3.640) | 0.117 |
| Complete revascularization | 0.403 (0.232–0.700) | 0.001 | 0.677 (0.346–1.321) | 0.253 |
| ACEIs/ARBs at discharge | 2.933 (1.596–5.391) | 0.001 | 1.659 (0.825–3.335) | 0.155 |