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Microbial pathway for biosynthesis of tetrahydrofolate (H4folate). Enzymes, shown in italics, are GTPCH, guanosine triphosphate (GTP) cyclohydrolase; PPase, phosphatase; DHNA, dihydroneopterin aldolase; HPPK, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; DHPS, dihydropteroate synthase; FPGS, folylpolyglutamate synthase; DHFR, dihydrofolate reductase. The target enzymes in this study, HPPK and DHFR, are highlighted in red.
