Table 1. Enzymatic and Cellular Inhibition Data of Compounds to Evaluate the SAR.

^aPRMT5-MEP50 enzyme inhibition (5.0 nM enzyme concentration in assay), mean for n ≥ 2.

^bInhibition of symmetric arginine dimethylation of SmD1/3 proteins in A549 cancer cells after 2 days incubation, detected by immuno histochemistry, mean for n ≥ 3.