Table 2. Anti-proliferation Activities of Compounds 14–22 and 28–32.
| Compound No. | BxPc3 2.5 μM (%) | Mia-capa2 2.5 μM (%) | HCT116 2.0 μM (%) | HCT116 IC50 (μM)ab |
|---|---|---|---|---|
| 15 | 46.4 | 68.2 | 59.3 | NTc |
| 16 | 27.9 | 71.3 | 52.0 | NT |
| 17 | 44.0 | 70.9 | 59.7 | 1.101 ± 0.023 |
| 18 | 45.2 | 65.2 | 48.8 | NT |
| 19 | 7.1 | 67.3 | 43.4 | NT |
| 20 | 42.1 | 73.4 | 35.3 | NT |
| 21 | 23.2 | 64.0 | 49.6 | NT |
| 22 | 61.3 | 68.4 | 83.6 | 0.162 ± 0.012 |
| 28 | 53.0 | 62.2 | 60.3 | NT |
| 29 | 42.2 | 66.4 | 60.4 | NT |
| 30 | 21.8 | 63.2 | 60.5 | NT |
| 31 | 52.1 | 54.4 | 55.6 | NT |
| 32 | 37.1 | 57.2 | 60.1 | NT |
| 14 | 11.2 | 59.1 | 14.0 | 3.341 ± 0.011 |
| JQ1 | 9.1 | 56.2 | 23.2 | 4.212 ± 0.015 |
| ABBV-075 | 36.8 | 64.3 | 69.5 | 0.550 ± 0.009 |
a
Data are expressed as the mean ± SD from the dose–response curves of at least three independent experiments.
b
IC50 values are shown as mean values of at least three determinations unless specified otherwise.
c
Not tested.