Table 2. Effect of MB/MV Analogues (1–5) on the Cellular Viability of Primary FRDA Fibroblasts against Erastin-Induced Ferroptotic Cell Death^a.

Compound	Erastin challenge cell survival EC50 (nM)
MB	43 ± 3
MV	27 ± 3
1a	39 ± 3
1b	15 ± 2
2a	37 ± 3
2b	11 ± 1
3a	29 ± 3
3b	10 ± 1
4a	35 ± 1
4b	15 ± 1
5a	55 ± 6
5b	22 ± 2
Lip-1	22 ± 4
Fer-1	33 ± 4
α-TOH	>500

^aThe calculated EC₅₀ values were determined graphically from the dose–response curves using the nonlinear regression curve fit analysis model.