Table 3. Inhibition of HIV-1IIIB and Cytotoxicity in GHOST CXCR4 Cellsa.
| compd | EC50 (μM) | TC50 (μM) | TI |
|---|---|---|---|
| 1a | 0.96 ± 0.09 | 153.3 ± 2.5 | 160 |
| 3a | 144.5 ± 24.7 | 553.4 ± 10.9 | 3.8 |
| IT1t | 0.022 ± 0.0006 | >1.0 | >45 |
a
EC50: concentration of compound required to achieve 50% inhibition of virus replication in GHOST CXCR4 cells and determined by reverse transcriptase activity assay. TC50: concentration of compound required to achieve 50% reduction in GHOST CXCR4 cells and determined by XTT assay. The values are the mean ± standard deviation (SD). TI: therapeutic index, ratios of TC50/EC50.