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. 2020 Sep 3;11(11):2253–2260. doi: 10.1021/acsmedchemlett.0c00391

Figure 3.

Figure 3

Concentration-inhibition curves of 14a (A) and 14b (B) at human recombinant soluble CD73 (red circles), human membrane-bound CD73 natively expressed in the triple negative breast cancer cell line MDA-MB-231 (blue circles), and rat recombinant soluble CD73 (green circles). Data points are means ± standard error (SEM) from 3 separate experiments. Determined Ki values for 14a: MDA-MB-231 cells, 4.59 nM; human soluble CD73, 2.98 nM; rat soluble CD73, 26.0 nM. Determined Ki value for 14b: human soluble CD73, 12.6 nM.