Table 1. Functional Properties Displayed by l-Glu, dl-TBOA, and 15a–d at hEAAT1-HEK293, hEAAT2-HEK293, hEAAT3-HEK293, and rEAAT4-tsA201 Cell Lines in the [³H]-d-Aspartate Uptake Assay^e.

^aIFDScore of the compound pose shown in the table was the one with the highest overlay quality like the reference ligand TFB-TBOA of EAAT1_cryst complex (PDB: 5mju).

^bIC₅₀ values were estimate from fitted concentration-inhibition curves that were not fully completed in the concentration ranges tested (up to 300 μM).

^cIFDScore of 15b poses were the two proposed binding models displayed in Figure 4d–e, respectively.

^dThe purity of compound 15c tested was 80%.

^eIC₅₀ values are given in μM with pIC₅₀ ± S.E.M. values in brackets, and all data are based on 3 independent experiments (n = 3).