Table 2.
Clinical Characteristics of Subjects with Chronic Hypersensitivity Pneumonitis
| Characteristic | Biopsy (n = 26) | Transplant (n = 56) | Total | P Value |
|---|---|---|---|---|
| Age, yr | 61.9 ± 9.7 | 58.2 ± 10.8 | 59.4 ± 10.6 | 0.15 |
| Sex | n = 26 | n = 55 | n = 81 | 0.57 |
| M | 11 (42) | 27 (48) | 38 (47) | |
| F | 15 (58) | 28 (52) | 43 (53) | |
| Smoke | n = 26 | n = 47 | n = 73 | |
| Ever | 17 (65) | 23 (49) | 40 (55) | 0.18 |
| Never | 9 (35) | 24 (51) | 33 (45) | — |
| Institution | <0.001 | |||
| LTRC | 24 (92) | 14 (25) | 38 (46) | |
| UCSF | 2 (8) | 34 (61) | 36 (44) | |
| NJH | 0 (0) | 8 (14) | 8 (10) | |
| MUC5B genotype | 0.32 | |||
| GG | 16 (62) | 36 (64) | 52 (63) | |
| GT | 9 (35) | 20 (36) | 29 (35) | |
| TT | 1 (4) | 0 (0) | 1 (1) | |
| Minor allele frequency | 0.217 | 0.179 | 0.189 | — |
| Antigen exposure | n = 26 | n = 48 | n = 74 | |
| Bird | 8 (31) | 16 (34) | 24 (33) | 1 |
| Feather | 13 (50) | 11 (23) | 24 (33) | 0.036 |
| Mold | 12 (46) | 15 (32) | 27 (36) | 0.32 |
| Multiple antigens | 11 (42) | 9 (16) | 20 (27) | <0.001 |
| Unknown | 7 (27) | 34 (61) | 41 (55) | 0.053 |
| Medication | n = 26 | n = 48 | n = 74 | |
| Corticosteroid | 7 (27) | 27 (56) | 34 (46) | 0.027 |
| IS | 1 (4) | 12 (25) | 13 (18) | 0.025 |
| Pulmonary function tests | n = 26 | n = 43 | n = 69 | |
| %FEV1 | 84.5 ± 24.0 | 46.6 ± 21.0 | 70.0 ± 28.9 | <0.001 |
| %FVC | 80.1 ± 21.2 | 41.3 ± 17.6 | 56.2 ± 26.8 | <0.001 |
| %DlCO | 59.3 ± 21.5 | 25.0 ± 9.1 | 40.8 ± 23.5 | <0.001 |
Definition of abbreviations: IS = immunosuppressant; LTRC = Lung Tissue Research Consortium; NJH = National Jewish Health; UCSF = University of California, San Francisco.
Continuous variables are shown as mean ± SD, and categorical variables are shown as n (%).