Table 3.
Clinical Characteristics of Subjects with Idiopathic Pulmonary Fibrosis
| Characteristic | Biopsy (n = 36) | Transplant (n = 67) | Total | P Value |
|---|---|---|---|---|
| Age, yr | 60.9 ± 8.4 | 60.0 ± 8.2 | 60.3 ± 8.3 | 0.56 |
| Sex | 0.39 | |||
| M | 22 (61) | 35 (52) | 57 (55) | |
| F | 14 (39) | 32 (48) | 46 (45) | |
| Smoke | n = 33 | n = 62 | n = 95 | 0.18 |
| Ever | 23 (70) | 32 (52) | 55 (58) | |
| Never | 10 (30) | 30 (48) | 40 (42) | |
| Institution | <0.001 | |||
| LTRC | 35 (97) | 19 (28) | 54 (52) | |
| UCSF | 1 (3) | 32 (48) | 33 (32) | |
| PT | 0 (0) | 14 (21) | 14 (14) | |
| VU | 0 (0) | 2 (3) | 2 (2) | |
| MUC5B genotype | 0.21 | |||
| GG | 16 (44) | 38 (57) | 54 (52) | |
| GT | 19 (53) | 24 (36) | 43 (42) | |
| TT | 1 (3) | 5 (7) | 6 (6) | |
| Minor allele frequency | 0.292 | 0.253 | 0.267 | — |
| Antigen exposure | n = 31 | n = 9 | n = 40 | |
| Bird | 11 (35) | 3 (34) | 14 (35) | 0.91 |
| Feather | 13 (42) | 5 (56) | 18 (45) | 0.47 |
| Mold | 5 (16) | 2 (25) | 7 (18) | 0.67 |
| Multiple antigens | 7 (23) | 3 (34) | 10 (25) | 0.51 |
| Unknown | 11 (35) | 3 (34) | 14 (35) | 0.9 |
| Medication | n = 33 | n = 9 | n = 42 | |
| Corticosteroid | 17 (52) | 6 (67) | 23 (55) | 0.41 |
| IS | 7 (21) | 3 (33) | 10 (24) | 0.45 |
| Pulmonary function tests | n = 31 | n = 10 | n = 41 | |
| %FEV1 | 64.8 ± 25.5 | 59.2 ± 15.6 | 63.4 ± 23.4 | 0.69 |
| %FVC | 61.9 ± 24.3 | 56 ± 16.9 | 60.5 ± 22.6 | 0.72 |
| %DlCO | 33 ± 19.5 | 26 ± 10.2 | 31.2 ± 17.8 | 0.63 |
Definition of abbreviations: IS = immunosuppressant; LTRC = Lung Tissue Research Consortium; PT = Pittsburgh University; UCSF = University of California, San Francisco; VU = Vanderbilt University.
Continuous variables are shown as mean ± SD, and categorical variables are shown as n (%).