Table 4.
Clinical Characteristics of Control Subjects
| Characteristic | Biopsy (n = 40) | Transplant (n = 63) | Total | P Value |
|---|---|---|---|---|
| Age, yr | 62.5 ± 7.4 | 58.2 ± 11.3 | 59.9 ± 10.2 | 0.053 |
| Sex | 0.1 | |||
| M | 13 (33) | 32 (51) | 45 (44) | |
| F | 27 (67) | 31 (49) | 58 (56) | |
| Smoke | n = 37 | n = 59 | n = 96 | 0.29 |
| Ever | 18 (49) | 35 (59) | 53 (55) | |
| Never | 19 (51) | 24 (41) | 43 (45) | |
| Institution | <0.001 | |||
| LTRC | 40 (100) | 17 (27) | 57 (55) | |
| UCSF | 0 (0) | 9 (14) | 9 (9) | |
| PT | 0 (0) | 37 (59) | 37 (36) | |
| MUC5B genotype | 0.81 | |||
| GG | 32 (80) | 48 (76) | 80 (78) | |
| GT | 7 (18) | 14 (22) | 21 (20) | |
| TT | 1 (2) | 1 (2) | 2 (2) | |
| Minor allele frequency | 0.113 | 0.127 | 0.117 | — |
| Antigen exposure | n = 35 | n = 11 | n = 46 | |
| Bird | 9 (26) | 3 (27) | 12 (26) | 0.61 |
| Feather | 21 (60) | 8 (73) | 29 (63) | 0.92 |
| Mold | 9 (26) | 2 (18) | 11 (24) | 0.68 |
| Multiple antigens | 11 (31) | 3 (27) | 14 (30) | 0.79 |
| Unknown | 10 (29) | 1 (9) | 11 (24) | 0.19 |
| Medication | n = 39 | n = 15 | n = 54 | |
| Corticosteroid | 3 (8) | 1 (7) | 4 (7) | 0.9 |
| IS | 0 (0) | 0 (0) | 0 (0) | — |
| Pulmonary function tests | n = 39 | n = 16 | n = 54 | |
| %FEV1 | 100.7 ± 16.1 | 90.5 ± 7.0 | 96.9 ± 15.2 | 0.092 |
| %FVC | 99.8 ± 16.6 | 89.9 ± 7.5 | 72.0 ± 16.7 | 0.017 |
| %DlCO | 74.5 ± 18.0 | 66.5 ± 12.0 | 97.7 ± 14.3 | 0.083 |
Definition of abbreviations: IS = immunosuppressant; LTRC = Lung Tissue Research Consortium; PT = Pittsburgh University; UCSF = University of California, San Francisco.
Continuous variables are shown as mean ± SD, and categorical variables are shown as n (%).