Table 5.
Commonly Differentially Expressed Genes in Both CHP and IPF
| Gene Name | Base Mean | log2 Fold Change | P Value | Adjusted P Value |
|---|---|---|---|---|
| SPRR1A | 212.75 | 7.63 | 3.81 × 10−27 | 4.22 × 10−24 |
| AC009086.2 | 10.57 | 6.65 | 6.55 × 10−4 | 2.17 × 10−3 |
| PRSS2 | 232.53 | 5.36 | 1.28 × 10−22 | 4.97 × 10−20 |
| KLK6 | 9.05 | 4.95 | 3.40 × 10−19 | 5.77 × 10−17 |
| LGALS7B | 1,070.95 | 4.87 | 4.24 × 10−24 | 2.17 × 10−21 |
| COL17A1 | 266.77 | 4.75 | 1.63 × 10−41 | 2.70 × 10−37 |
| FDCSP | 600.65 | 4.74 | 1.80 × 10−17 | 1.96 × 10−15 |
| S100A2 | 10,007.22 | 4.66 | 4.14 × 10−39 | 2.29 × 10−35 |
| KRT14 | 51.91 | 4.28 | 5.76 × 10−17 | 5.71 × 10−15 |
| IGFL2 | 307.46 | 4.24 | 2.24 × 10−33 | 6.20 × 10−30 |
| CXCL13 | 1,041 | 3.98 | 9.75 × 10−19 | 1.51 × 10−16 |
| CALML3 | 10.8 | 3.92 | 9.98 × 10−12 | 2.50 × 10−14 |
| COMP | 559.6 | 3.87 | 8.54 × 10−29 | 1.09 × 10−25 |
| GREM1 | 222.34 | 3.86 | 4.46 × 10−17 | 4.52 × 10−15 |
| KRTAP2-3 | 8.83 | 3.86 | 2.52 × 10−7 | 2.10 × 10−6 |
| GPR87 | 261.82 | 3.72 | 1.20 × 10−17 | 1.38 × 10−15 |
| LGALS7 | 389.94 | 3.47 | 8.54 × 10−14 | 1.33 × 10−8 |
| DSC3 | 57.1 | 3.44 | 5.47 × 10−8 | 5.44 × 10−7 |
| FAM83A | 127.66 | 3.44 | 9.97 × 10−27 | 8.73 × 10−24 |
| TMPRSS4 | 871.29 | 3.34 | 7.19 × 10−21 | 1.78 × 10−18 |
| CHRM2 | 27.51 | −2.37 | 5.92 × 10−11 | 1.22 × 10−9 |
| CA2 | 141.79 | −2.39 | 8.47 × 10−12 | 2.15 × 10−14 |
| SLC6A4 | 1,562.49 | −2.43 | 9.98 × 10−7 | 7.19 × 10−6 |
| BTNL8 | 117.4 | −2.43 | 3.03 × 10−24 | 1.73 × 10−21 |
| AL096711.2 | 64.67 | −2.44 | 8.99 × 10−24 | 4.27 × 10−21 |
| KLRG2 | 49.16 | −2.49 | 2.37 × 10−22 | 8.78 × 10−20 |
| SLC14A1 | 161.79 | −2.51 | 6.31 × 10−12 | 1.66 × 10−14 |
| MME | 847.08 | −2.51 | 4.02 × 10−24 | 2.16 × 10−21 |
| ERICH4 | 29.72 | −2.53 | 9.25 × 10−23 | 3.66 × 10−20 |
| C8B | 61.34 | −2.53 | 3.76 × 10−8 | 3.90 × 10−7 |
| GRM8 | 15.09 | −2.57 | 1.49 × 10−12 | 4.51 × 10−11 |
| ADCY8 | 12.86 | −2.67 | 9.26 × 10−13 | 2.95 × 10−11 |
| NKD1 | 56.01 | −2.72 | 5.22 × 10−15 | 2.96 × 10−13 |
| FAM167A | 32.04 | −2.81 | 2.13 × 10−14 | 1.01 × 10−12 |
| SLCO1A2 | 30.14 | −2.92 | 3.32 × 10−13 | 1.19 × 10−11 |
| BTNL9 | 1,746.64 | −2.96 | 2.70 × 10−29 | 4.99 × 10−26 |
| ADRA1A | 99.65 | −3.35 | 4.05 × 10−38 | 1.43 × 10−34 |
| LAMP3 | 110.46 | −3.42 | 3.72 × 10−8 | 3.87 × 10−7 |
| ITLN2 | 511.01 | −3.77 | 6.78 × 10−16 | 4.80 × 10−14 |
| FAM71A | 6.87 | −3.84 | 1.46 × 10−6 | 1.00 × 10−5 |
Definition of abbreviations: CHP = chronic hypersensitivity pneumonitis; IPF = idiopathic pulmonary fibrosis.
Top 20 up- and downregulated genes in CHP. The table shows differentially expressed genes overlapped in IPF and CHP. The table was sorted by log2 fold change in CHP with transplanted samples.