Table 7.

Pathological Features of Subjects with Chronic Hypersensitivity Pneumonitis

	Biopsy (n = 26)	Transplant (n = 45)	Total (N = 71)	P Value
Site				0.14
Right upper lobe	4	19	23
Right lower lobe	12	14	26
Left upper lobe	3	7	10
Left lower lobe	7	8	15
Pathological findings*
Airway-centered inflammation	5/14/6/1	24/8/11/2	42/29 (59%)	0.008
Granuloma	12/8/4/2	29/7/6/3	30/41 (42%)	0.42
Giant cells	12/10/4/0	23/17/7/3	36/35 (51%)	0.32
Peribronchiolar metaplasia	11/6/5/4	18/11/13/3	42/29 (59%)	0.59
Organizing pneumonia	15/8/3/0	36/7/2/0	20/51 (28%)	0.13
Fibrosis	11/6/9/0	1/4/23/17	59/12 (83%)	<0.001
Honeycombing	20/4/2/0	17/12/6/8	34/37 (48%)	0.02
Fibroblastic foci	13/6/7/0	14/15/14/2	44/27 (63%)	0.34
Lymphocytic inflammation	6/11/8/1	1/21/21/2	64/7 (84%)	0.039
Germinal center	21/4/1/0	35/7/3/0	15/56 (21%)	0.88
Diagnosis	16 (62%)	26 (51%)	42/29 (59%)	0.42

The table shows sampling site and pathological features for each sampling methods and total cases. Numbers are presented as absent/rare/moderate/severe in biopsy and transplant cohorts, and present/absent in total cases in pathological features. Percentages are provided with positive cases/total subjects (N = 71).

^*Absent: 0, rare: 1, moderate: 2, severe: 3, and present/absent.