Table 1.
Baseline Characteristics of Study Subjects Stratified According to Helicobacter pylori Status
| Characteristic | Total (n=221) |
H. pylori-negative (n=84) | H. pylori-positive (n=137) | p-value |
|---|---|---|---|---|
| Male sex | 107 (48.4) | 36 (42.9) | 71 (51.8) | 0.195 |
| Age, yr | 55.2±12.0 | 55.8±13.6 | 54.9±11.3 | 0.605 |
| BMI, kg/m2 | 24.52±14.54 | 26.34±23.24 | 23.43±3.22 | 0.149 |
| Current & ex-smoker | 89 (40.5) | 31 (36.0) | 58 (42.6) | 0.399 |
| Alcohol drinker | 123 (56.2) | 48 (57.1) | 75 (55.6) | 0.818 |
| Family history of gastric cancer | 95 (43.0) | 36 (42.9) | 59 (43.1) | 0.976 |
| Gastric cancer & dysplasia | 99 (44.8) | 30 (35.7) | 69 (50.4) | 0.034* |
| Gastric dysplasia | 28 (28.3) | 11 (36.7) | 17 (24.6) | |
| WD or MD ADC | 45 (45.5) | 9 (30.0) | 36 (52.2) | |
| PD ADC or SRC | 26 (26.2) | 10 (33.3) | 16 (23.2) | |
| Atrophic gastritis | 129 (58.4) | 34 (40.5) | 95 (69.3) | <0.001* |
| Intestinal metaplasia | 113 (50.9) | 30 (35.7) | 83 (60.1) | <0.001* |
| Serum pepsinogen | ||||
| I | 54.14±40.97 | 41.85±28.43 | 60.66±44.18 | 0.001* |
| II | 19.25±16.36 | 12.67±12.42 | 22.90±16.74 | <0.001* |
| I/II ratio | 3.48±2.14 | 4.28±2.61 | 2.99±1.62 | <0.001* |
| I/II ratio ≤3 | 110 (50.5) | 26 (31.3) | 84 (62.2) | <0.001* |
Data are presented as number (%) or mean±SD.
BMI, body mass index; WD, well differentiated; MD, moderately differentiated; ADC, adenocarcinoma; PD, poorly differentiated; SRC, signet ring cell carcinoma.
*Statistically significant, p<0.05.