Table 5.
Univariate and Multivariate Analyses of Factors Associated with Overall Survival in Patients with EJA
| Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age (≥60 yr vs <60 yr) | 0.995 (0.955–1.037) | 0.819 | |||
| Sex (female vs male) | 0.750 (0.343–1.640) | 0.471 | |||
| Smoke (yes vs no) | 1.226 (0.620–2.426) | 0.558 | |||
| Alcohol (yes vs no) | 2.007 (1.025–3.931) | 0.042 | |||
| Tumor size (≥5 cm vs <5 cm) | 1.759 (0.874–3.538) | 0.113 | |||
| T (T4 vs T1+T2+T3) | 3.114 (1.217–7.966) | 0.018 | 3.362 (1.310–8.625) | 0.012 | |
| N (N1+N2+N3 vs N0) | 1.996 (0.917–4.346) | 0.082 | |||
| M (M1 vs M0) | 7.445 (2.225–24.904) | 0.001 | 11.303 (3.101–41.202) | <0.001 | |
| G (G2+G3 vs G1) | 3.734 (0.897–15.553) | 0.070 | |||
| pTNM-stage (III+IV vs I+II) | 2.183 (0.963–4.949) | 0.062 | |||
| IGFBP7 (≥3.436 vs <3.436) | 0.433 (0.195–0.962) | 0.040 | 0.351 (0.157–0.786) | 0.011 | |
Multivariate analysis, Cox proportional hazards regression model. Variables were adopted for their prognostic significance according to the univariate analysis.
EJA, esophagogastric junction adenocarcinoma; HR, hazard ratio; CI, confidence interval; IGFBP7, insulin-like growth factor binding protein 7.