Table 2.
Overall Survival Analysis of Responders and Nonresponders According to the RECIST 1.1 and mRECIST
| Response criteria | Time point | Response | No. of patient | Mean OS (95% CI) |
p-value (log-rank) |
Univariate HR (95% CI) |
p-value |
|---|---|---|---|---|---|---|---|
| RECIST 1.1 | At 1 month | Responders | 2 | Not reached | 0.427 | - | |
| Nonresponders | 99 | 55.0 (48.6–61.3) | 21.072 (too wide) | 0.598 | |||
| At 3 months | Responders | 13 | 64.9 (55.2–74.6) | 0.130 | - | ||
| Nonresponders | 81 | 52.6 (45.4–59.8) | 4.208 (0.557–31.779) | 0.164 | |||
| At 6 months | Responders | 20 | 60.0 (50.1–70.0) | 0.291 | - | ||
| Nonresponders | 51 | 54.6 (45.4–63.8) | 2.013 (0.536–7.561) | 0.300 | |||
| Best response | Responders | 23 | 60.9 (51.6–70.2) | 0.115 | - | ||
| Nonresponders | 79 | 53.4 (45.9–61.0) | 2.596 (0.759–8.881) | 0.128 | |||
| mRECIST | At 1 month | Responders | 31 | 61.4 (55.9–66.9) | 0.008 | - | |
| Nonresponders | 70 | 49.1 (40.8–57.5) | 5.736 (0.133–24.676) | 0.019 | |||
| At 3 months | Responders | 47 | 60.4 (52.5–68.2) | 0.022 | - | ||
| Nonresponders | 47 | 48.4 (38.8–58.0) | 3.145 (1.118–8.845) | 0.030 | |||
| At 6 months | Responders | 42 | 60.2 (52.2–68.2) | 0.061 | - | ||
| Nonresponders | 29 | 47.3 (35.0–59.6) | 2.887 (0.907–9.187) | 0.073 | |||
| Best response | Responders | 58 | 61.3 (54.7–67.9) | 0.001 | - | ||
| Nonresponders | 44 | 44.7 (34.0–55.5) | 4.594 (1.775–11.893) | 0.002 |
RECIST, Response Evaluation Criteria in Solid Tumors; mRECIST, modified RECIST; OS, overall survival; CI, confidence interval; HR, hazard ratio.