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DNA binding by the GRF domain inhibits NEIL3 ICL unhooking activity. A, schematic of proteins used in this experiment. B, representative gel for ICL unhooking by WT mNEIL3 against a lagging-strand AP-dA ICL fork substrate. C, ICL unhooking activity of WT, GRFmut, and ΔGRF mNEIL3 proteins against the leading-strand AP-dA ICL fork. D, quantification of data shown in B and C (means ± S.D. for three independent experiments).
