Figure 8.

Demonstration of C74's ability to reduce RCC cell proliferation in vitro and tumor growth in vivo. A and B, box plots summarizing the results of indicated doses of C74 on proliferation (A) and serum-induced chemotactic migration of RVN cells (B). **, p < 0.01; ***, p < 0.001. For proliferation experiments, C74 was added on the day of cell seeding (D0) and replenished daily during the culture period. C and D, effect of in vivo administration of C74 versus DMSO on tumor growth (C, representative tumors; D, quantification) from subcutaneously implanted RENCA cells in BALB/c mice (data summarized from nine and ten DMSO- and C74-treated mice pooled from two independent experiments).