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. 2020 Sep 21;295(46):15427–15437. doi: 10.1074/jbc.RA120.013815

Figure 1.

Figure 1.

ZDHHC5 and ZDHHC8 are preferentially targeted to DRG axons compared with all other PATs. A, images of HA fluorescent signal (left panels) and merged HA, GFP, and DAPI (blue, to detect nuclei) signals (right panels) from individual cultured DRG neurons co-infected with control lentivirus expressing GFP plus a second virus expressing the indicated HA-tagged ZDHHC-PAT. PAT numbering reflects updated gene names (2). Scale bar, 20 μm. B, quantified axon/soma fluorescence intensity ratio for each of the indicated PATs, normalized to GFP. Blue dotted line, mean axon/soma fluorescence intensity ratio for all PATs from all determinations. One-way ANOVA was used with the Bonferroni post hoc test (F(23, 220) = 9.332, p < 0.0001); ****, p < 0.0001; **, p < 0.01, compared with average axon/soma ratio for all PATs from all determinations. n = 7–13 neurons/condition. Bars, mean ± S.D. (error bars).