Figure 5.

ZDHHC5/8 control Gp130 surface expression. A, surface fractions (left column) and total lysates from cultured DRG neurons infected with the indicated viruses were immunoblotted with the indicated antibodies. B, quantified data from A reveal that Zdhhc5/8 knockdown significantly reduces surface/total Gp130 (left histogram; *, p < 0.05, t test) but does not affect surface/total levels of the axonal palmitoyl-protein neurofascin (right histogram; n.s., nonsignificant, t test, n = 8 and n = 4 determinations/condition, respectively). Bars, mean ± S.D. (error bars).