Figure 1.
The three ER stress–sensing proteins that activate UPR signaling. Activation of IRE1, PERK, and ATF6 promotes integrated signaling that translationally and transcriptionally remodels ER and cellular proteostasis.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.