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. 2020 Nov 16;17:180. doi: 10.1186/s12985-020-01450-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The insertion of CD2v did not change the proliferation and virulence of PRV-ΔgE/ΔgI/ΔTK. a The 50 TCID50 virus was inoculated into 5 × 10⁵ Vero cells and cultured for 48 h. The growth of plaques in Vero cells was observed by crystal violet staining. b Statistical results of the plaque area. c 1 × 10³ TCID50 viruses were inoculated into 5 × 10⁵ Vero cells to allow virus proliferation, and the virus sample was collected at 12 h, 24 h, 36 h, 48 h. The virus titer was calculated by the Karber method to draw a one-step growth curve. d Five-week-old SPF ICR mice were injected (i.m) with 5 × 10⁵ TCID50 viruses into the right hind leg to observe mice's survival daily, and the survival curve was drawn (n = 15/each group). Unpaired t-test or two-way ANOVA was performed by GraphPad Prism 5.0, GraphPad Software (San Diego, CA, USA), *p < 0.05, **p < 0.01, ***p < 0.001, ns (not significant)