Skip to main content
. 2020 Oct 26;117(45):27954–27961. doi: 10.1073/pnas.2013044117

Fig. 4.

Fig. 4.

Influence of ESBP6 overexpression on coumaric acid production. (A) Coumaric acid titer and maximum OD600 in strains with (QL01_ESBP6 and QL38_ESBP6) and without (QL01_URA and QL38_URA) the overexpression of ESBP6. Error bars represent the SD from three biological replicates. (B) Schematic illustration of the interaction between aromatic acids, the transcription factors Aro80 and War1, and the transporters Esbp6 and Pdr12. In the presence of AAAs, Aro80 activates the transcription of genes necessary for degrading these compounds, which leads to the production of fusel acids and fusel alcohols. Fusel acid presence putatively induces the transcription of PDR12 (through War1) and both Pdr12 and Esbp6 are responsible for excreting these compounds to the medium. Abbreviations: AAA, aromatic amino acids (l-phenylalanine, l-tyrosine, and l-tryptophan); FSA, fusel acids (phenylacetic acid, 4-hydroxyphenylacetic acid, and indoleacetic acid); CA, coumaric acid; and FA, ferulic acid.