Fig. 3.

Antibiotics targeting bacterial translation inhibit the growth and survival of cells latently infected with KSHV. Treatment of KSHV-infected TIME cells suppresses cell growth in a dose-dependent manner with both chloramphenicol (A) and tigecycline (B; mean with SEM of three replicate experiments). KSHV-infected PEL, BCBL1 and AIDS body cavity-based lymphoma 1 (BC1), cells exhibit a dose-dependent induction of cell death for both chloramphenicol (C) and tigecycline (D), which is not seen in B cell lymphomas lacking KSHV (the EBV negative Burkitt’s lymphoma BJAB, and the EBV positive Burkitt’s lymphoma RAJI).