Table 2.

Influence of HLA class I TD on progression to AIDS-1987 in seroconverters (n = 954) and HIV-1 viremia (n = 4.306)

	HR per log10 TD increase†	P value	VL est. per log10 TD increase‡	P value
HLA-A/B/C	1.5	0.001	0.17	3 × 10−36
HLA-A	1.2	0.2	0.10	8 × 10−9
HLA-B	1.3	0.008	0.06	4 × 10−12
HLA-C	1.1	0.6	0.10	2 × 10−4

^†Cox proportional hazards model adjusted for race and B*57, B*27, B*35-Px allelic effects.

^‡Longitudinal VL analysis adjusted for random effects due to each HLA-A, HLA-B, and HLA-C allele present in the cohort, the time after enrollment, and diploid HLA coding.