Fig. 1.

β-cell specific deletion of APPL2 impairs glucose-stimulated insulin secretion and induces glucose intolerance. Male RIP-APPL2 KO mice, their WT littermates, and RIP-Cre controls fed with STC were used. (A) GTT, 2g/kg in 6 h fasted 16-wk-old mice. (B) The area under the curve (AUC) of GTT performed at different ages. (C) Insulin secretion during GTT in A. (D) Insulin tolerance test in the 14-wk-old mice. n = 5 for each group. All data are presented as the mean ± SD. Significance was determined using one-way ANOVA with Bonferroni correction. *P < 0.05, **P < 0.01 (KO vs. WT), #P < 0.05, and ##P < 0.01 (KO vs. RIP-Cre).