Table 3b.

Multivariable Cox regression analysis for overall survival of high-risk patients

	Univariate analysis			Multivariate analysis
Covariate	HR	95% CI	P-value	HR	95% CI	P-value
Age at resection	1.02	1.01-1.02	0.001	1.01	1.00-1.02	0.005
Right-sided tumor	1.46	1.13-1.87	0.004	1.32	1.00-1.74	0.05
Node positive primary tumor	1.04	0.77-1.39	0.82	1.36	0.97-1.90	0.08
Disease-free interval (cont.)	1.01	1.00-1.02	0.009	1.00	0.99-1.01	0.97
Number CRLM (cont.)	1.08	1.05-1.10	<0.001	1.06	1.04-1.09	<0.001
Diameter CRLM (cont.)	1.04	1.02-1.07	<0.001	1.04	1.01-1.07	0.006
Preoperative CEA (cont.)	1.00	1.00-1.00	0.75	1.00	1.00-1.00	0.17
Irradical resection (R1)	1.38	1.09-1.76	0.008	1.33	1.02-1.75	0.04
Additional ablation	1.04	0.82-1.32	0.74	1.35	1.00-1.81	0.05
Year of surgery	0.97	0.96-0.98	0.008	0.97	0.95-0.99	0.001
Perioperative SYS	0.76	0.61-0.95	0.02	0.73	0.57-0.94	0.02