Table 3.
Top upstream regulators
| Upstream regulator | Molecule type | Activation z score | P | No. of target genes |
|---|---|---|---|---|
| CDKN2A | Transcription regulator | 5.39 | 3.53E-15 | 46 |
| TP53 | Transcription regulator | 4.15 | 3.45E-27 | 179 |
| SMARCB1 | Transcription regulator | 3.75 | 1.96E-05 | 20 |
| RBL1 | Transcription regulator | 3.69 | 7.77E-09 | 17 |
| PAX6 | Transcription regulator | 3.51 | 4.25E-05 | 22 |
| CDKN1A | Kinase | 3.49 | 3.12E-22 | 53 |
| RB1 | Transcription regulator | 3.27 | 3.62E-07 | 44 |
| PPARGC1A | Transcription regulator | 2.75 | 1.10E-02 | 24 |
| NLRP3 | Other | 2.70 | 2.21E-04 | 12 |
| GATA1 | Transcription regulator | 2.53 | 9.72E-15 | 45 |
| NEUROD1 | Transcription regulator | 2.38 | 1.44E-02 | 6 |
| CREBBP | Transcription regulator | 2.27 | 5.13E-03 | 27 |
| NKX2-2 | Transcription regulator | 2.24 | 9.27E-06 | 6 |
| TFEB | Transcription regulator | 2.23 | 2.55E-02 | 5 |
| BDNF | Growth factor | 2.12 | 1.58E-04 | 28 |
| IRGM1 | Other | 2.12 | 4.34E-04 | 8 |
| NR5A2 | Ligand-dependent nuclear receptor | 1.96 | 1.29E-02 | 10 |
| PPARG | Ligand-dependent nuclear receptor | 1.90 | 1.01E-05 | 41 |
| HNF1A | Transcription regulator | 1.73 | 2.36E-02 | 29 |
| ESR1 | Ligand-dependent nuclear receptor | –2.16 | 3.93E-06 | 91 |
| NKX2-3 | Transcription regulator | –2.28 | 3.40E-03 | 18 |
| REST | Transcription regulator | –2.41 | 1.45E-03 | 15 |
| GATA6 | Transcription regulator | –2.44 | 4.91E-02 | 13 |
| AREG | Growth factor | –2.72 | 7.70E-04 | 11 |
| MITF | Transcription regulator | –3.04 | 2.42E-15 | 41 |
| FOXM1 | Transcription regulator | –3.10 | 1.41E-03 | 14 |
| VEGF | Group | –3.28 | 5.08E-09 | 50 |
| TAL1 | Transcription regulator | –3.32 | 9.02E-03 | 17 |
| E2F | Group | –3.65 | 7.88E-14 | 28 |
| EGFR | Kinase | –3.81 | 5.88E-06 | 37 |
| CSF2 | Cytokine | –4.16 | 1.77E-06 | 45 |
| RABL6 | Other | –4.69 | 3.35E-15 | 22 |
| ERBB2 | Kinase | –4.87 | 2.76E-13 | 82 |
| MYC | Transcription regulator | –6.81 | 1.23E-21 | 123 |