Table 1:
Newborn Electrocardiographic QT Intervals and Hydroxychloroquine Exposure
| ID | Gestational Age (wks) |
Sex | Birth Weight (kg) |
Maternal 1T HCQ | Maternal 2T HCQ | Maternal 3T HCQ | Maternal Delivery HCQ | Cord HCQ | QTc Interval |
|---|---|---|---|---|---|---|---|---|---|
| 3A | 34 | M | 2.8 | NA | 1306 | NA | < 100 | 156 | 370 |
| 3B | 34 | F | 2.2 | 114 | 405 | ||||
| 10 | 41 | F | 3.01 | 161 | 1205 | < 100 | 311 | 693 | 448 |
| 11 | 37 | F | 2.55 | 830 | 870 | 662 | 711 | 1198 | 415 |
| 14 | 41 | F | 3.36 | < 100 | 1153 | 161 | < 100 | <100 | 436 |
| 17 | 35 | F | 2.07 | 656 | 718 | 1176 | 1330 | 320 | 417 |
| 20 | 39 | M | 3.74 | 1270 | 801 | 795 | 742 | 632 | 410 |
| 21 | 39 | F | 3.32 | < 100 | 604 | 688 | 453 | 389 | 390 |
| 22 | 41 | F | 3.92 | < 100 | < 100 | 179 | < 100 | <100 | 412 |
| 24 | 38 | F | NA | NA | NA | NA | 640 | 609 | 420 |
| 26 | 39 | F | 3.27 | 569 | 1132 | 1601 | 1637 | 1143 | 458 |
| 29 | 39 | F | 3.59 | 669 | 525 | 925 | 1097 | 868 | 384 |
| 33 | 35 | M | 2.90 | 869 | 603 | 798 | 723 | 507 | 422 |
| 36 | 39 | M | 3.18 | 671 | 660 | 1992 | 1204 | 975 | 436 |
| 40 | 39 | M | 3.03 | 951 | 3264 | 890 | 717 | 682 | 397 |
| 41 | 37 | F | 2.18 | 1195 | 900 | 905 | 571 | 1778 | 416 |
| 42 | 39 | M | 3.06 | 611 | 891 | 969 | NA | NA | 412 |
| 44 | 39 | F | 3.90 | 1256 | 1309 | 1058 | 1661 | 1349 | 442 |
| 45 | 35 | F | 2.14 | 1308 | 1149 | NA | NA | NA | 484 |
| 49 | 36 | F | 2.32 | < 100 | 341 | 566 | 735 | 631 | 438 |
| 52 | 39 | M | 3.51 | 509 | 1063 | 905 | 810 | 375 | 424 |
| 54 | 39 | M | 3.17 | 671 | 601 | 615 | 854 | 1130 | 425 |
| 55 | 38 | F | 2.77 | 1251 | 1445 | 983 | NA | NA | 393 |
| 57 | 39 | F | 2.83 | 134 | 1235 | 900 | 1513 | 738 | 445 |
| 60 | 39 | F | 3.49 | < 100 | 700 | NA | 839 | 836 | 445 |
| 61 | 38 | M | 3.42 | 678 | 884 | 1017 | 938 | 585 | 492 |
| 62 | 40 | M | 2.99 | NA | NA | NA | 1202 | 966 | 433 |
| 69 | 37 | F | 2.00 | 721 | 794 | 805 | 855 | 486 | 439 |
| 71 | 37 | M | 3.03 | 527 | 1409 | 1999 | 537 | 671 | 442 |
| 73 | 35 | M | NA | 597 | 459 | 481 | 363 | 746 | 413 |
| 74 | 35 | M | 2.63 | 761 | 916 | 783 | 660 | 348 | 422 |
| 75 | 37 | F | 3.73 | 1152 | 1406 | 1251 | 1842 | 1678 | 335 |
| 77 | 35 | M | 2.04 | 274 | 552 | NA | 1007 | 655 | 401 |
| 80 | 37 | M | 3.04 | 707 | 831 | 335 | 688 | 154 | 347 |
| 82 | 37 | M | 3.77 | 1866 | 1251 | 829 | NA | NA | 451 |
| 83 | 39 | M | 3.69 | 930 | 213 | 849 | 715 | 1124 | 404 |
| 84 | 39 | M | 2.54 | 362 | 740 | 866 | 819 | 533 | 450 |
| 85 | 38 | M | 3.42 | 405 | 1234 | 854 | 790 | 627 | 394 |
| 87 | 39 | M | 2.69 | 609 | 527 | 626 | 957 | 658 | 441 |
| 88 | 38 | M | NA | 1005 | 1153 | 801 | 1173 | 658 | 426 |
| 89 | 39 | F | NA | 808 | 552 | 642 | 1168 | 811 | 471 |
| 90 | 38 | F | NA | 1363 | 862 | 1694 | 1028 | 1366 | 419 |
| 91 | 36 | F | 3.07 | 363 | NA | NA | NA | NA | 454 |
| 93 | 39 | F | 3.01 | 250 | 914 | 1287 | 834 | 637 | 353 |
| 95 | 37 | F | 2.86 | 663 | 711 | 788 | 832 | 696 | 417 |
The five infants with prolonged QTc intervals are indicated in bold. All hydroxychloroquine (HCQ) levels are displayed in ng/mL, and they correspond to levels during the first, second and third trimesters and at delivery, as well as levels in the infant’s cord blood at birth. For samples < 100 ng/ml, which meant below level of detection, 50ng g/ml was used to calculate average exposure. QTc intervals are displayed in msec.