TABLE 5.
Results of Crude and Multivariable-Adjusted Generalized Estimating Equation Analysis: Factors Associated With Nugent’s BV Among Women With Community State Types CST-IVA or CST-IVB
| Time-Adjusted Univariate, Odds Ratio (95% CI), P Value |
Multivariable-Adjusted Model 1* Covariates Only (n = 303), Adjusted Odds Ratio (95% CI), P Value |
Multivariable-Adjusted Model 2* Covariates and Meatal Taxa (n = 296), Adjusted Odds Ratio (95% CI), P Value |
|
|---|---|---|---|
| CST-IVA vs. CST-IVB | 1.90 (1.07–3.35), P = 0.027 | 1.90 (0.97–3.73), P = 0.063 | 1.91 (0.91–4.00), P = 0.087 |
| Woman is HSV-2 seropositive | 1.63 (0.94–2.83), P = 0.083 | 1.62 (0.92–2.85), P = 0.095 | 1.75 (0.97–3.17), P = 0.065 |
| Woman is HIV positive | 2.47 (1.21–5.03), P = 0.013 | 2.48 (1.16–5.34), P = 0.020 | 2.30 (1.00–5.32), P = 0.051 |
| T. vaginalis detected on wet mount | 2.41 (0.92–6.32), P = 0.074 | ||
| Male partner is HIV positive | 2.18 (0.99–4.80), P = 0.052 | ||
| Male partner is circumcised | 0.66 (0.39–1.10), P = 0.109 | 0.73 (0.43–1.24), P = 0.243 | 0.79 (0.45–1.41), P = 0.427 |
| Male partner reported using condom at last sex | 1.85 (0.98–3.49), P = 0.058 | ||
| Penile relative abundance†: Dialister species | 1.16 (1.01–1.34), P = 0.034 | ||
| Penile relative abundance†: Megasphaera species | 1.22 (1.09–1.37), P = 0.001 | ||
| Penile relative abundance†: Brevibacterium species | 1.13 (1.02–1.25), P = 0.019 | ||
| Visit | |||
| Baseline | Reference | Reference | Reference |
| 1 mo | 1.23 (0.77–1.96), P = 0.396 | 1.32 (0.79–2.21), P = 0.282 | 1.66 (0.96–2.88), P = 0.069 |
| 6 mo | 1.63 (0.93–2.88), P = 0.089 | 1.36 (0.74–2.50), P = 0.322 | 1.49 (0.77–2.88), P = 0.231 |
| 12 mo | 1.41 (0.80–2.48), P = 0.234 | 1.05 (0.55–1.98), P = 0.890 | 1.17 (0.60–2.28), P = 0.653 |
*Model 1 and model 2 are simultaneously adjusted for all variables presented under each.
†Penile relative abundance data are center log ratio transformed before analysis.