Table 3.
Comparison of preoperative and intraoperative recipient and donor graft factors before and after PS matching
| Group | Before propensity score matched analysis | After propensity score matched analysis | ||||||
| Normal vitamin B12 | High vitamin B12 | P value | SD | Normal vitamin B12 | High vitamin B12 | P value | SD | |
| N | 156 | 323 | 99 | 99 | ||||
| Preoperative factors | ||||||||
| Age (years) | 54 (49–59) | 52 (47–59) | 0.084 | −0.126 | 55 (50–60) | 54 (48–60) | 0.395 | −0.105 |
| Sex (male) | 116 (74.4%) | 215 (66.6%) | 0.084 | −0.165 | 70 (70.7%) | 67 (67.7%) | 0.644 | −0.064 |
| Body mass index (kg/m2) | 23.9 (22.3–26.0) | 24.4 (22.2–27) | 0.146 | 0.164 | 24.2 (22.7–26.2) | 24.2 (21.9–26.5) | 0.695 | −0.049 |
| Nephrotoxic drug exposure | 17 (10.9%) | 27 (8.4%) | 0.367 | −0.092 | 11 (11.1%) | 13 (13.1%) | 0.663 | 0.073 |
| Calcineurin inhibitor level | 7.4 (6.5–8.7) | 7.3 (5.8–8.9) | 0.95 | 0.051 | 7.5 (6.7–8.8) | 7.3 (6.5–9.2) | 0.879 | 0.016 |
| Diabetes | 38 (24.4%) | 87 (26.9%) | 0.547 | 0.058 | 29 (29.3%) | 26 (26.3%) | 0.634 | −0.068 |
| Hypertension | 34 (21.8%) | 60 (18.6%) | 0.406 | −0.083 | 24 (24.2%) | 22 (22.2%) | 0.736 | −0.052 |
| MELD | 14.5 (9–25) | 14 (9–23) | 0.39 | 0.983 | 10 (8–14) | 12 (9–15) | 0.073 | 0.185 |
| Encephalopathy | 5 (3.2%) | 27 (8.4%) | 0.034 | 0.186 | 4 (4.0%) | 7 (7.1%) | 0.352 | 0.109 |
| Varix | 40 (25.6%) | 84 (26%) | 0.932 | 0.008 | 28 (28.3%) | 25 (25.3%) | 0.63 | −0.069 |
| Ascites | 49 (31.4%) | 185 (57.3%) | <0.001 | 0.522 | 39 (39.4%) | 39 (39.4%) | 1 | 0 |
| Ejection fraction | 64 (62–67) | 64.54 (62–67) | 0.74 | 0.045 | 64.5 (62–67) | 64.5 (62–67) | 0.851 | 0.026 |
| Diastolic dysfunction | 80 (51.3%) | 144 (44.6%) | 0.168 | −0.135 | 48 (48.5%) | 47 (47.5%) | 0.887 | −0.02 |
| Laboratory variables | ||||||||
| Haemoglobin (g/L) | 108 (91–124) | 92 (80–108) | <0.001 | −0.609 | 100 (85–120) | 101 (87–118) | 0.82 | 0.007 |
| White blood cell count (×109/L) | 3.4 (2.4–5.0) | 4.5 (3.0–7.7) | <0.001 | 0.4 | 3.3 (2.4–5.0) | 3.9 (2.8–5.7) | 0.121 | 0.189 |
| Albumin (g/dL) | 3.3 (2.8–3.8) | 2.9 (2.6–3.3) | <0.001 | 0.034 | 3.1 (2.7–3.8) | 3.0 (2.7–3.4) | 0.072 | 0.101 |
| Platelet count (×109/L) | 72 (52.3–119.8) | 57 (41–85) | <0.001 | −0.335 | 64 (51–103) | 67 (46–105) | 0.988 | 0.12 |
| Sodium (mEq/L) | 141 (138–142) | 138 (134–141) | <0.001 | −0.462 | 140 (136–142) | 140 (135–141) | 0.1 | −0.142 |
| Potassium (mEq/L) | 4 (3.7–4.2) | 4 (3.6–4.4) | 0.864 | 0.05 | 4 (3.7–4.2) | 4.1 (3.8–4.4) | 0.396 | −0.001 |
| Calcium (mEq/L) | 8.4 (8.1–8.8) | 8.4 (7.9–8.8) | 0.339 | 0.043 | 8.4 (7.9–8.8) | 8.3 (7.9–8.7) | 0.47 | −0.02 |
| Glucose (mg/dL) | 103 (91–126) | 110 (92–142) | 0.027 | 0.203 | 107 (89–130) | 106 (93–126) | 0.999 | −0.113 |
| Creatinine (mg/dL) | 0.84 (0.69–0.96) | 0.85 (0.65–1.31) | 0.14 | 0.238 | 0.84 (0.68–1.06) | 0.78 (0.63–1.02) | 0.423 | 0.147 |
| Lactate (mg/dL) | 3.7 (3.0–4.6) | 3.6 (2.8–4.9) | 0.567 | −0.017 | 3.6 (3.0–4.6) | 3.6 (2.7–4.9) | 0.432 | −0.034 |
| Ammonia | 90 (65–140.75) | 98 (66–155) | 0.485 | 0.032 | 96 (66–145) | 97 (61–145) | 0.91 | −0.084 |
| Intraoperative factors | ||||||||
| Total surgery duration (min) | 513 (455–593) | 510 (460–570) | 0.699 | −0.108 | 510 (450–575) | 500 (455–585) | 0.9 | 0.01 |
| Severe PRS (class >1) | 76 (48.7%) | 176 (54.5%) | 0.236 | 0.116 | 49 (49.5%) | 44 (44.4%) | 0.476 | 0.101 |
| Average of vital signs | ||||||||
| MBP (mm Hg) | 76.9 (71.5–84.3) | 76 (69.4–82.4) | 0.053 | 0.058 | 76.9 (71.6–84.3) | 76 (71–84) | 0.401 | −0.005 |
| HR (beats/min) | 85.8 (77.8–95) | 88 (80.8–97.3) | 0.019 | 0.192 | 87 (80–97.3) | 88 (79.5–96.0) | 0.69 | 0.033 |
| CVP (mm Hg) | 9 (7.5–10.5) | 9 (7.5–10.5) | 0.522 | 0.124 | 9 (7.5–10.5) | 9 (7.5–10.8) | 0.889 | 0.06 |
| Blood product transfusion (unit) | ||||||||
| Packed red blood cells | 5 (2–12) | 9 (5–15) | <0.001 | 0.349 | 5 (3–1) | 4 (6–11) | 0.313 | 0.025 |
| Fresh frozen plasma | 5 (3–7) | 9 (5–13) | <0.001 | 0.496 | 5 (3–9) | 7 (4–10) | 0.046 | 0.124 |
| Platelet concentrate | 0 (0–6) | 6 (0–12) | <0.001 | 0.219 | 4 (0–6) | 5 (0–12) | 0.307 | 0.092 |
| Hourly fluid infusion (mL/kg/hour) | 9.6 (7.2–11.5) | 9.4 (6.5–13.1) | 0.551 | 0.12 | 9.2 (6.4–12.7) | 10.1 (8.2–13.1) | 0.485 | 0.086 |
| Hourly urine output (mL/kg/hour) | 1.7 (0.9–2.5) | 1.1 (0.5–1.8) | <0.001 | −0.564 | 1.7 (0.8–2.3) | 1.3 (0.8–2.3) | 0.184 | −0.124 |
| Donor-graft factors | ||||||||
| Age (years) | 31 (25–41) | 34 (17–41) | 0.229 | 0.068 | 34 (25–42) | 32 (25–41) | 0.653 | −0.061 |
| Sex (male) | 64 (40.3%) | 95 (29.4%) | 0.011 | −0.254 | 39 (39.4%) | 40 (40.4%) | 0.891 | 0.022 |
| GRWR (%) | 1.2 (1.1–1.6) | 1.3 (1.0–1.8) | 0.361 | 0.035 | 1.3 (1.1–1.6) | 1.3 (1.1–1.7) | 0.767 | −0.06 |
| Graft ischaemic time (min) | 102.5 (60–182.8) | 127 (83–182.8) | 0.003 | 0.093 | 104 (64–182.8) | 106 (73–182.8) | 0.46 | −0.01 |
| Fatty change (%) | 3.8 (0–5) | 4.6 (1–5) | 0.397 | 0.176 | 5 (1–5) | 4.6 (1–5) | 0.179 | −0.091 |
Values are expressed as medians (IQR) or numbers (%).
CVP, central venous pressure; GRWR, graft recipient weight ratio; HR, heart rate; MBP, mean blood pressure; MELD, model for end-stage liver disease; PRS, postreperfusion syndrome.