Table 1.

Summary of objectives and outcomes

Objectives	Outcomes
Biomarkers of organ injury
Heart	High-sensitivity cardiac troponin T (primary outcome)
	N-terminal pro-B-type natriuretic peptide
Brain	Glial fibrillar acidic protein
	Myelin basic protein
	Neuron-specific enolase (NSE)
Liver	Alanine aminotransferase
Intestine	Intestinal-type fatty acid binding protein
Skeletal muscle	Creatine kinase
Global tissue dysoxia	Lactate
Organ function	Sequential Organ Failure Assessment score on days 2, 3, 4, 7, 10, 14 and 28 while in the ICU (an additional measurement is taken on day 1 (baseline))
Resource utilisation	Duration of mechanical ventilation
	Duration of renal replacement therapy
	Duration of vasopressor therapy
	Duration of ICU stay
	Duration of hospital stay
Adverse events	Clinically detected supraventricular arrhythmia
	Stroke
	Acute kidney injury (KDIGO stage 3)
	Limb ischaemia
	Intestinal ischaemia
Mortality	90 days
	6 months
Cognitive impairment	Telephone Interview for Cognitive Status at 6 months

All biomarkers of organ injury and lactate are measured in plasma (except for NSE, measured in serum) at days 3 and 7, with an additional measurement at baseline (day 1).

ICU, intensive care unit; KDIGO, kidney disease improving global outcomes.