Figure 3.

Follicle distribution per culture day. Follicle distribution as a percentage of the total amount of follicles per culture day in transgender men and oncological patients. Estimated follicle counts in primordial, intermediate, primary and secondary follicles in transgender men (red) and oncological patients (green). Significant lower estimated primordial follicle counts were found on Days 2, 4 and 6 in the oncological group (−78%; 95% CI −94% to −21%; P = 0.02 on Day 2) and on Day 4 and 6 in the transgender cohort (−64%; 95% CI −83% to −23%; P = 0.008 on Day 4). Primary follicle counts were estimated to increase significantly in oncological patients on Day 6 (estimated increase of 170%; 5% CI +14% to +589%; P = 0.025). Significant higher estimated counts of secondary follicles were observed in transgender men on Day 4 (+367%; 95% CI +26% to +1630%; P = 0.021). All follicle counts are compared to the counts on Day 0. *Statistically significant in comparison to Day 0 (P < 0.05).