Table 1.

Study subject characteristics.

Azole antifungal agent	FLCZ	VRCZ
Total cases (male)	28 (11)	4 (3)
Age (yr)	60 (33–88)	73 (70–79)
Azole dose (mg/d)	200 (50–400)	195 (150–200)
Warfarin dose (mg/d):
Warfarin alone	2.5 (0.875–4.5)	2.375 (1.5–3.0)
With azole antifungals	2.25 (0.875–3.75)	2.285 (0.75–5.25)
Reason for warfarin administration
Deep vein thrombosis	2	0
Atrial fibrillation	3	3
Heart valvular regurgitation	3	0
Post-valve-replacement	2	0
Cardiogenic cerebral infarction	3	1
Rheumatic cardiopathy	15	0
Reason for azole administration
Candida albicans fungus	28	0
Aspergillus infection	0	4