Table 1.
Analysis of the correlation between TGFβ2 and immune cell related genes and markers in TIMER.
| COAD | STAD | ACC | |||||||||||
| None | Purity | None | Purity | None | Purity | ||||||||
| Description | Gene markers | cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P |
| CD8+ T cell | CD8A | 0.13 | ∗∗∗ | 0.04 | 0.26 | 0.12 | ∗∗ | 0.12 | ∗ | 0.01 | .91 | 0.12 | .31 |
| CD8B | 0.09 | ∗ | 0.02 | 0.49 | 0.11 | ∗ | 0.12 | ∗ | 0.10 | .37 | 0.03 | .78 | |
| T cell (general) | CD3D | 0.06 | .18 | 0.05 | 0.36 | 0.05 | .28 | 0.04 | .43 | 0.05 | .68 | 0.15 | .20 |
| CD3E | 0.14 | ∗ | 0.05 | 0.31 | 0.06 | .19 | 0.05 | .35 | 0.06 | .61 | 0.05 | .65 | |
| CD2 | 0.18 | ∗∗ | 0.10 | 0.05 | 0.11 | .02 | 0.11 | .03 | 0.04 | .74 | 0.10 | .40 | |
| B cell | CD19 | 0.04 | .35 | 0.05 | 0.33 | 0.13 | ∗ | 0.10 | .06 | 0.04 | .70 | 0.06 | .63 |
| CD79A | 0.15 | ∗ | 0.04 | 0.42 | 0.14 | ∗ | 0.12 | .02 | 0.04 | .70 | 0.11 | .37 | |
| Monocyte | CD86 | 0.39 | ∗∗∗ | 0.33 | ∗∗∗ | 0.18 | ∗∗ | 0.18 | ∗∗ | 0.06 | .58 | 0.19 | .11 |
| CSF1R | 0.38 | ∗∗∗ | 0.30 | ∗∗∗ | 0.31 | ∗∗∗ | 0.29 | ∗∗∗ | 0.13 | .25 | 0.07 | .58 | |
| TAM | CCL2 | 0.50 | ∗∗∗ | 0.45 | ∗∗∗ | 0.32 | ∗∗∗ | 0.33 | ∗∗∗ | 0.20 | .07 | 0.13 | .26 |
| CD68 | 0.18 | ∗∗∗ | 0.12 | 0.01 | 0.05 | .28 | 0.06 | .25 | 0.16 | .15 | 0.10 | .40 | |
| IL10 | 0.26 | ∗∗∗ | 0.20 | ∗∗∗ | 0.27 | ∗∗∗ | 0.29 | ∗∗∗ | 0.20 | .08 | 0.15 | .21 | |
| M1 Macrophage | NOS2 | 0.25 | ∗∗∗ | 0.27 | ∗∗∗ | 0.18 | ∗∗ | 0.18 | ∗∗ | 0.46 | ∗∗∗ | 0.48 | ∗∗∗ |
| IRF5 | 0.07 | .11 | 0.07 | 0.13 | 0.17 | ∗∗ | 0.17 | ∗∗ | 0.00 | .97 | 0.07 | .58 | |
| PTGS2 | 0.27 | ∗∗∗ | 0.23 | ∗∗∗ | 0.33 | ∗∗∗ | 0.33 | ∗∗∗ | 0.10 | .39 | 0.13 | .28 | |
| M2 Macrophage | CD163 | 0.40 | ∗∗∗ | 0.34 | ∗∗∗ | 0.24 | ∗∗∗ | 0.23 | ∗∗∗ | 0.13 | .27 | 0.06 | .60 |
| VSIG4 | 0.35 | ∗∗∗ | 0.27 | ∗∗∗ | 0.27 | ∗∗∗ | 0.30 | ∗∗∗ | 0.07 | .51 | 0.02 | .86 | |
| MS4A4A | 0.35 | ∗∗∗ | 0.28 | ∗∗∗ | 0.26 | ∗∗∗ | 0.27 | ∗∗∗ | 0.21 | .06 | 0.15 | .20 | |
| Neutrophils | CEACAM8 | 0.21 | ∗∗∗ | 0.20 | ∗∗∗ | 0.02 | .74 | 0.02 | .74 | 0.01 | .90 | 0.02 | .89 |
| ITGAM | 0.38 | ∗∗∗ | 0.33 | ∗∗∗ | 0.26 | ∗∗∗ | 0.26 | ∗∗∗ | 0.22 | .05 | 0.20 | .09 | |
| CCR7 | 0.20 | ∗∗∗ | 0.12 | 0.01 | 0.22 | ∗∗∗ | 0.20 | ∗∗∗ | 0.01 | .96 | 0.05 | .65 | |
| Natural killer cell | KIR2DL1 | 0.05 | .28 | 0.01 | 0.85 | 0.09 | .08 | 0.07 | .15 | 0.18 | .11 | 0.16 | .19 |
| KIR2DL3 | 0.03 | .55 | 0.00 | 0.99 | 0.07 | .14 | 0.05 | .34 | 0.14 | .22 | 0.07 | .54 | |
| KIR2DL4 | 0.03 | .56 | 0.09 | 0.07 | 0.12 | .01 | 0.14 | ∗ | 0.08 | .48 | 0.19 | .10 | |
| KIR3DL1 | 0.04 | .35 | 0.01 | 0.91 | 0.08 | .11 | 0.07 | .16 | 0.15 | .20 | 0.11 | .36 | |
| KIR3DL2 | 0.09 | .07 | 0.02 | 0.72 | 0.01 | .87 | 0.00 | .94 | 0.07 | .51 | 0.07 | .55 | |
| KIR3DL3 | 0.03 | .58 | 0.04 | 0.46 | 0.10 | .03 | 0.12 | .02 | 0.04 | .75 | 0.06 | .63 | |
| KIR2DS4 | 0.08 | .08 | 0.06 | 0.24 | 0.02 | .72 | 0.00 | .99 | 0.21 | .07 | 0.15 | .19 | |
| Dendritic cell | HLA-DPB1 | 0.21 | ∗∗∗ | 0.12 | 0.01 | 0.05 | .30 | 0.04 | .47 | 0.13 | .24 | 0.04 | .72 |
| HLA-DQB1 | 0.10 | .03 | 0.00 | 0.98 | 0.09 | .07 | 0.11 | .03 | 0.05 | .68 | 0.03 | .83 | |
| HLA-DRA | 0.23 | ∗∗∗ | 0.14 | ∗ | 0.04 | .44 | 0.05 | .35 | 0.14 | .21 | 0.05 | .69 | |
| HLA-DPA1 | 0.26 | ∗∗∗ | 0.18 | ∗∗ | 0.01 | .84 | 0.00 | .99 | 0.14 | .20 | 0.05 | .66 | |
| CD1C | 0.37 | ∗∗∗ | 0.31 | ∗∗∗ | 0.31 | ∗∗∗ | 0.32 | ∗∗∗ | −0.18 | .11 | -0.11 | .35 | |
| NRP1 | 0.67 | ∗∗∗ | 0.64 | ∗∗∗ | 0.57 | ∗∗∗ | 0.57 | ∗∗∗ | 0.38 | ∗∗ | 0.32 | ∗ | |
| ITGAX | 0.42 | ∗∗∗ | 0.37 | ∗∗∗ | 0.28 | ∗∗∗ | 0.28 | ∗∗∗ | 0.03 | .80 | 0.08 | .50 | |
| Th1 | TBX21 | 0.12 | .02 | 0.08 | 0.10 | 0.07 | .15 | 0.03 | .78 | 0.06 | .62 | 0.12 | .02 |
| STAT4 | 0.21 | ∗∗∗ | 0.22 | ∗∗∗ | 0.20 | ∗∗ | 0.01 | .90 | 0.11 | .33 | 0.21 | ∗∗∗ | |
| STAT1 | 0.25 | ∗∗∗ | 0.03 | 0.52 | 0.05 | .38 | 0.20 | .08 | 0.27 | .02 | 0.25 | ∗∗∗ | |
| IFNG | 0.02 | .74 | 0.08 | 0.10 | 0.09 | .09 | 0.21 | .07 | 0.31 | ∗ | 0.02 | .74 | |
| TNF | 0.07 | .17 | 0.09 | 0.06 | 0.09 | .09 | 0.03 | .77 | 0.09 | .45 | 0.07 | .17 | |
| Th2 | GATA3 | 0.21 | ∗∗∗ | 0.25 | ∗∗∗ | 0.26 | ∗∗∗ | 0.35 | ∗ | 0.33 | ∗ | 0.21 | ∗∗∗ |
| STAT6 | 0.16 | ∗∗ | 0.05 | 0.29 | 0.05 | .32 | 0.37 | ∗∗ | 0.38 | ∗∗ | 0.16 | ∗∗ | |
| STAT5A | 0.01 | .81 | 0.17 | ∗∗ | 0.17 | ∗∗ | 0.28 | .01 | 0.24 | .04 | 0.01 | .81 | |
| IL13 | 0.11 | .03 | 0.08 | 0.11 | 0.07 | .15 | 0.22 | .05 | 0.19 | .10 | 0.11 | .03 | |
| Tfh | BCL6 | 0.24 | ∗∗∗ | 0.39 | ∗∗∗ | 0.37 | ∗∗∗ | 0.01 | .92 | 0.03 | .80 | 0.24 | ∗∗∗ |
| IL21 | 0.11 | .02 | 0.02 | 0.75 | 0.01 | .81 | NA | NA | NA | NA | 0.11 | .02 | |
| Th17 | STAT3 | 0.14 | ∗ | 0.29 | ∗∗∗ | 0.27 | ∗∗∗ | 0.12 | .31 | 0.11 | .37 | 0.14 | ∗ |
| IL17A | 0.12 | .01 | 0.08 | 0.09 | 0.09 | .07 | 0.18 | .10 | 0.18 | .13 | 0.12 | .01 | |
| Treg | FOXP3 | 0.26 | ∗∗∗ | 0.05 | 0.29 | 0.03 | .52 | 0.31 | ∗ | 0.32 | ∗ | 0.26 | ∗∗∗ |
| CCR8 | 0.35 | ∗∗∗ | 0.21 | ∗∗∗ | 0.21 | ∗∗∗ | 0.16 | .16 | 0.21 | .08 | 0.35 | ∗∗∗ | |
| STAT5B | 0.25 | ∗∗∗ | 0.37 | ∗∗∗ | 0.36 | ∗∗∗ | 0.29 | ∗ | 0.26 | .03 | 0.25 | ∗∗∗ | |
| TGFB1 | 0.22 | ∗∗∗ | 0.38 | ∗∗∗ | 0.37 | ∗∗∗ | 0.26 | .02 | 0.31 | ∗ | 0.22 | ∗∗∗ | |
| T cell exhaustion | PDCD1 | 0.03 | .56 | 0.07 | 0.18 | 0.07 | .21 | 0.12 | .29 | 0.26 | .03 | 0.03 | .56 |
| CTLA4 | 0.22 | ∗∗∗ | 0.10 | 0.05 | 0.10 | .06 | 0.07 | .54 | 0.17 | .14 | 0.22 | ∗∗∗ | |
| LAG3 | 0.04 | .39 | 0.01 | 0.86 | 0.00 | .94 | 0.29 | .01 | 0.34 | ∗ | 0.04 | .39 | |
| HAVCR2 | 0.30 | ∗∗∗ | 0.13 | ∗ | 0.13 | .01 | 0.08 | .46 | 0.02 | .88 | 0.30 | ∗∗∗ | |
| GZMB | 0.05 | .34 | 0.08 | 0.09 | 0.10 | .04 | 0.03 | .79 | 0.02 | .84 | 0.05 | .34 | |