Table 5.

The optimal dose of metformin for patients with varying degrees of renal function.

		Dosing interval of 8 hours	Dosing interval of 12 hours
Different renal function stages	eGFR(mL/min/1.73m2)	Dose(mg)	Dose(mg)
G3a	45–59	750	1000
G2	60–89	1275	1700
G1	90–119	1500	2000
Augmented renal clearance	≥120	2550	3000