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Receiver operating characteristic curve analysis for DIFF2 in predicting freedom from major amputation. At a DIFF2 value of ≧ -1.3 °C, it predicted freedom from major amputation with a sensitivity of 70.5%, specificity of 54.0%, positive predictive value of 59.7%, and negative predictive value of 65.4% (area under curve 0.738, 95% confidence interval [CI],0.601-0.876; P = .004).
