Table 1.

Definitions of American Joint Committee on Cancer 7th edition and 8th edition tumor-node-metastasis staging systems for pancreatic neuroendocrine neoplasms and analysis for non-functional-pancreatic neuroendocrine neoplasms in the present study.

	AJCC 7th edition staging system for p-EACsA(N = 152 +78) C	AJCC 8th edition staging system for G1/G2 p-NETsB(N = 152)	AJCC 8th edition staging system for G3 p-NECsB(N = 78)
T/N/M staging definitions
T1	Tumor limited to the pancreas, < 2 cm in greatest diameter;	Tumors limited to pancreas, 2 cm or less in greatest dimension;	T tumor 2 cm or less in greatest dimension;
T2	Tumor limited to the pancreas, > 2 cm in greatest diameter;	Tumors limited to pancreas more than 2 cm but less than 4 cm in greatest dimension;	Tumor more than 2 cm but no more than 4 cm in greatest dimension;
T3	Tumor extends beyond the pancreas, but not involving the celiac axis or superior mesenteric artery;	Tumors limited to pancreas, more than 4 cm in greatest dimension or tumors invading duodenum or bile duct;	Tumor more than 4 cm in greatest dimension;
T4	Tumor involves the celiac axis or superior mesenteric artery (unresectable tumor).	Tumors perforates visceral peritoneum (serosa) or invades other organs or adjacent structures.	Tumor involves coeliac axis, superior mesenteric artery and/or common hepatic artery.
N0	No regional lymph node metastasis;	No regional lymph node metastasis;	No regional lymph node metastasis;
N1	Regional lymph node metastasis;	Regional lymph node metastasis.	Metastases in 1 to 3 regional lymph nodes;
N2	NA.	NA.	Metastases in 4 or more regional lymph nodes.
M0	No distant metastasis;	No distant metastasis;	No distant metastasis;
M1	Distant metastasis.	Distant metastasis.	Distant metastasis.
Clinical staging definitions--- (Cases)
Stage I	T1 N0 M0 (A) --- (52) D / (10) E;T2 N0 M0 (B) --- (19) / (13);	T1 N0 M0--- (52) D;	T1 N0 M0 (A) --- (10) E;T2 N0 M0(B) --- (7);
Stage II	T3 N0 M0 (A) --- (25) / (9);T1-3 N1 M0(B) --- (17) / (12);	T2 N0 M0(A) --- (12);T3 N0 M0(B) --- (28);	T3 N0 M0(A) --- (11);Any T N1 M0(B)--- (8);
Stage III	T4 Any N M0--- (20) / (16);	T4 N0 M0(A) --- (15);Any T N1 M0(B) --- (26);	Any T N2 M0--- (8);T4 Any N M0--- (16);
Stage IV	Any T Any N M1--- (19) / (18).	Any T Any N M1 --- (19).	Any T Any N M1--- (18).

Cross-tabulation of 3 AJCC TNM staging systems--- (Cases)
For NF-p-NENs by AJCC 7th system
	Stage I	Stage II	Stage III	Stage IV	Total
For G1/G2 NF-p-NETs by AJCC 8th system
Stage I	52	0	0	0	52
Stage II	19	21	0	0	40
Stage III	0	21	20	0	41
Stage IV	0	0	0	19	19
Total	71	42	20	19	152
For G3 NF-p-NECs by AJCC 8th system
Stage I	17	0	0	0	17
Stage II	6	13	0	0	19
Stage III	0	8	16	0	24
Stage IV	0	0	0	18	18
Total	23	21	16	18	78