Table 3.

Multivariate analysis of prognostic factors for non-functional pancreatic neuroendocrine neoplasms.

	AJCC 7th stage for all NF-p-NENsA		AJCC 8th stage for G1/G2 NF-p-NETsB		AJCC 8th stage for G3 NF-p-NECsC
Variable	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Patients gender
Female	1.0 (referent)		1.0 (referent)		1.0 (referent)
Male	1.29 (1.18–1.92)	.313	1.08 (0.98–1.52)	.147	1.12 (0.89–1.22)	.198
Age at diagnosis
<Median	1.0 (referent)		1.0 (referent)		1.0 (referent)
≥Median	1.75 (1.13–2.12)	.289	1.54 (1.09–1.95)	.147	1.42 (0.99–1.82)	.183
Diagnosis on admission
Incidental	1.0 (referent)		1.0 (referent)		1.0 (referent)
Symptomatic	1.32 (0.78–2.02)	.267	1.65 (1.13–1.89)	.235	1.44 (0.99–1.97)	.331
Tumor location
Head/uncinate	1.0 (referent)		1.0 (referent)		1.0 (referent)
Body/tail	1.82 (1.48–3.24)	.158	1.79 (1.25–2.48)	.246	2.04 (0.57–2.97)	.098
Surgical procedure		.146		.353		.278
Local resection	1.0 (referent)		1.0 (referent)		1.0 (referent)
Distal pancreatectomy	5.97 (3.29–12.04)	.041	5.54 (3.25–11.78)	.032	6.09 (3.47–13.65)	.015
Pancreaticoduodenectomy	7.83 (4.18–13.64)	.015	7.25 (3.11–10.86)	.025	8.12 (5.51–15.26)	.007
Biopsy	16.24 (6.36–33.07)	<.001	18.83 (7.25–38.36)	<.001	18.15 (7.07–34.25)	<.001
WHO 2010 grading classification		<.001		.039
G1	1.0 (referent)		1.0 (referent)		NA
G2	3.97 (3.02–7.64)	.048	4.14 (3.22–8.15)	.039
G3	18.52 (13.74–41.35)	<.001	NA
AJCC 7th stage for all NF-p-NENs		<.001
I	1.0 (referent)		NA		NA
II	1.53 (1.29–3.07)	.116
III	2.92 (2.75–7.46)	.352
IV	5.14 (4.13–1.13)	.024
AJCC 8th stage for G1/G2 NF-p-NETs				<.001
I	NA		1.0 (referent)		NA
II			1.46 (1.12–2.64)	.045
III			2.97 (2.19–6.46)	.023
IV			5.03 (3.53–9.02)	<.001
AJCC 8th stage for G3 NF-p-NECs						<.001
I	NA		NA		1.0 (referent)
II					1.57 (1.01–2.52)	.038
III					2.63 (2.05–6.48)	.017
IV					5.12 (3.36–8.45)	<.001