Table 1.
Structural parameters of tucatinib
| Definition | Value (in Å) | Definition | Value (in °) |
|---|---|---|---|
| R(1O–12C) | 1.44 | A(12C–1O–15C) | 105.18 |
| R(1O–15C) | 1.36 | A(26C–2O–31C) | 118.20 |
| R(2O–26C) | 1.39 | A(11C–3N–15C) | 106.35 |
| R(2O–31C) | 1.36 | A(15C–4N–16C) | 127.74 |
| R(3N–11C) | 1.48 | A(15C–4N–45H) | 114.54 |
| R(3N–15C) | 1.28 | A(16C–4N–45H) | 117.67 |
| R(4N–15C) | 1.36 | A(21C–5N–23C) | 131.47 |
| R(4N–16C) | 1.39 | A(21C–5N–49H) | 114.73 |
| R(4N–45H) | 1.01 | A(23C–5N–49H) | 113.77 |
| R(5N–21C) | 1.37 | A(20C–6N–29C) | 115.19 |
| R(5N–23C) | 1.40 | A(21C–7N–29C) | 117.13 |
| R(5N–49C) | 1.01 | A(10N–8N–33C) | 110.27 |
| R(6N–20C) | 1.37 | A(10N–8N–35C) | 126.30 |
| R(6N–29C) | 1.31 | A(33C–8N–35C) | 123.43 |
| R(7N–21C) | 1.32 | A(33C–9N–36C) | 102.33 |
| R(7N–29C) | 1.36 | A(8N–10N–36C) | 101.28 |
| R(8N–10C) | 1.35 | A(1O–15C–3N) | 119.22 |
| R(8N–33C) | 1.38 | A(1O–15C–4N) | 112.02 |
| R(8N–35C) | 1.36 | A(3N–15C–4N) | 128.77 |
| R(9N–33C) | 1.33 | A(18C–17C–20C) | 120.68 |
| R(9N–36C) | 1.35 | A(18C–17C–21C) | 124.02 |
| R(10N–36C) | 1.33 | A(20C–17C–21C) | 115.29 |
| R(24C–30C) | 1.50 | A(5N–21C–7N) | 120.56 |
| R(26C–28C) | 1.39 | A(5N–21C–17C) | 118.20 |
| R(28C–52H) | 1.09 | A(7N–21C–17C) | 121.24 |
| R(31C–32C) | 1.37 | A(5N–23C–25C) | 124.34 |
| A(5N–23C–27C) | 116.38 | ||
| A(25C–23C–27C) | 119.28 | ||
| A(31C–32C–33C) | 117.93 | ||
| A(31C–32C–57H) | 122.84 | ||
| A(33C–32C–57H) | 119.23 | ||
| A(8N–33C–9N) | 109.08 | ||
| A(8N–33C–32C) | 118.91 | ||
| A(9N–33C–32C) | 132.01 |