Table 4.

Non-linear optics property for tucatinib

Non-linear property	Tucatinib	Urea	p-nitro acetanilide	Comparison of tucatinib with urea and PNA
Dipole moment (μ)	2.74 D	1.73 D	0.91 D	1.58 times urea and 3.01 times PNA
Hyperpolarisability (β) (esu)	51.6*10−31	7.60*10−31	237.67*10−31	6.79 times urea and 0.21 times PNA
Mean polarisability (α0)	373.08*10−23	24.30*10−23	113.86*10−23	15.5 times greater than urea and 3.27 times PNA
Anisotropy of the polarisability (Δα) (esu)	897.38*10−23	0.85*10−23	5.29*10−23	1055 times greater than urea and 169 times PNA
Molar refractivity (MR) (esu)	9412.26	613.31	2873.74	15.34 times greater than urea and 3.2 times PNA