Table 2.
Amino acid descriptors of selected active pockets for S glycoprotein, ACE2, furin and TMPRSS2 proteins
| S glycoprotein | ACE2 | Furin | TMPRSS2 |
|---|---|---|---|
| Leu_335_E | Tyr_279_A | Ile_151_A | Val_76_A |
| Cys_336_E | Val_283_A | Leu_152_A | Cys_77_A |
| Pro_337_E | Phe_285_A | Asp_153_A | Gln_78_A |
| Phe_338_E | Gly_286_A | Asp_154_A | Asp_79_A |
| Gly_339_E | Gln_287_A | Asp_191_A | Trp_81_A |
| Phe_342_E | Lys_288_A | Asn_192_A | Asn_82_A |
| Asn_343_E | Pro_289_A | His_194_A | Asn_84_A |
| Ala_344_E | Asn_290_A | Arg_197_A | Tyr_85_A |
| Val_362_E | Ile_291_A | Cys_198_A | Ala_88_A |
| Ala_363_E | Met_366_A | Leu_227_A | Arg_91_A |
| Asp_364_E | Leu_370_A | Asp_228_A | Asp_92_A |
| Val_367_E | Glu_406_A | Ser_251_A | Phe_112_A_B |
| Leu_368_E | Ser_409_A | Ala_252_A | Met_119_A |
| Ser_371_E | Leu_410_A | Ser_253_A | Lys_120_A |
| Ser_373_E | Ser_411_A | Trp_254_A | Leu_121_A |
| Phe_374_E | Ala_413_A | Gly_255_A | Asn_122_A |
| Trp_436_E | Thr_414_A | Pro_256_A | Ala_125_A |
| Leu_441_E | Pro_415_A | Glu_257_A | Val_128_A |
| Arg_509_E | Lys_416_A | Asp_258_A | Asp_129_A |
| Leu_418_A | Asp_259_A | Ile_130_A | |
| Phe_428_A | Gly_260_A | Tyr_131_A | |
| Gln_429_A | Lys_261_A | Leu_134_A | |
| Glu_430_A | Thr_262_A | Tyr_135_A | |
| Asp_431_A | Val_263_A | Val_146_A | |
| Thr_434_A | Asp_264_A | Pro_281_A | |
| Glu_435_A | Trp_291_A | Thr_397_A | |
| Asn_437_A | Ala_292_A | Asp_398_A | |
| Phe_438_A | Ser_293_A | Tyr_401_A | |
| Lys_441_A | Gly_294_A | Arg_402_A | |
| Gln_442_A | Asn_295_A | Arg_405_A | |
| Ile_446_A | Asp_301_A | ||
| Phe_523_A | Ser_302_A | ||
| Gln_526_A | Cys_303_A | ||
| Cys_530_A | Cys_305_A | ||
| Leu_539_A | Asp_306_A | ||
| His_540_A | Thr_309_A | ||
| Lys_541_A | Glu_331_A | ||
| Cys_542_A | His_364_A | ||
| Tyr_587_A | Thr_367_A | ||
| Ser_368_A | |||
| Ala_371_A | |||
| Pro_372_A | |||
| Arg_519_A | |||
ACE2- angiotensin converting enzyme 2; TMPRSS2 – transmembrane serine protease 2