Table 4. Comparative analysis between the results of the present study and those reported in the literature for each medulloblastoma subtype.
| Present study data | Literature data | |
|---|---|---|
| Frequency | ||
| WNT | 16.3% | 11.0% 14 |
| SHH | 34.7% | 28.0% 14 |
| Non-WNT/non-SHH group | 49.0% | 61.0% 14 |
| Gender (M:F) | ||
| WNT | 0.6:1 | 1:1 14 , 25 |
| SHH | 3.2:1 | 1:1 14 , 25 |
| Non-WNT/non-SHH group | 2.4:1 | 2:1 14 , 25 |
| Age group | ||
| WNT | All 3-16 | Mostly 3-16 14 , 25 |
| SHH | Mostly 3-16 | Mostly <3 or >16 14 , 25 |
| Non-WNT/non-SHH group | Mostly 3-16 | <3 and 3-16 14 , 25 |
| Histology | ||
| WNT | Mostly classic | Mostly classic 14 , 25 |
| SHH | Mostly desmoplastic | Classic, desmoplastic, A/LC 14 , 25 |
| Non-WNT/non-SHH group | Mostly classic | Classic, A/LC 14 , 25 |
| Metastasis | ||
| WNT | 25% | Rare (9%) 14 , 25 |
| SHH | 23% | Unusual (17-22%) 14 , 25 |
| Non-WNT/non-SHH group | 70% | Very frequent (30-47%) 14 , 25 |
| Prognosis* | ||
| WNT | 75% | Better (>90%) 14 , 25 |
| SHH | 58.8% | Intermediate (68-75%) 14 , 25 |
| Non-WNT/non-SHH group | 66.7% | Worse (45-58%) 14 , 25 |
*Five-year survival; WNT: wingless; SHH: sonic hedgehog; M: male; F: female; A/LC: anaplastic/large cells.