Figure 1.

Threshold selection for percent cancer cells with qPTEN loss using maximally log-rank statistics. All 98 cases with PTEN loss from the training cohort were included in the analysis. Each data point in this figure represents between 1 and 3 patients because several cases showed overlapping values of % PTEN loss in cancer cells. Standardized log-rank statistics values were computed for each distinct threshold value of percent cancer cells with PTEN loss in the training cohort. The highest log-rank statistics value corresponded to a threshold of 65% and was chosen as an optimal threshold for identifying patients with shorter biochemical recurrence-free survival. Patients with low PTEN loss (1%–65% cancer cells) are shown as ● and high PTEN loss (>65% cancer cells) is represented as ♦. The thresholds for both percent cells and cores were selected using the same approach. PTEN = phosphatase and tensin homolog.