Video 4. In silico simulations of CTL movements around cognate tumouroid as agent-based processes.

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Motility models bootstrapped from experimental data. Gray: tumouroid; green: agents migrating without influence of chemoattractive signal; blue: agents encountering chemoattractant concentrations above threshold migrate directionally; red: agents infiltrating tumouroid. (Left) Agents arrive at tumouroid by random (non-directed) movement only. (Right) Agents arriving at tumouroid secrete diffusing chemoattractant that induces spatial bias in the movement of other agents towards tumouroid. Time in h:min.